Recombinant Human EXTL1, His-tagged

• Cat.No.: EXTL1-12605H
• Product Overview: Recombinant Human EXTL1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 328-676a.a.
• Description: This gene is a member of the multiple exostoses (EXT) family of glycosyltransferases, which function in the chain polymerization of heparan sulfate and heparin. The encoded protein harbors alpha 1,4- N-acetylglucosaminyltransferase activity, and is involved in chain elongation of heparan sulfate and possibly heparin.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: EXTL1 exostoses (multiple)-like 1 [ Homo sapiens ]
• Official Symbol: EXTL1
• Synonyms: exostoses (multiple)-like 1; 3515; Ensembl:ENSG00000158008; MGC70794; exostosin-like 1;exostosin-L;multiple exostosis-like protein;alpha-N-acetylglucosaminyltransferase II;glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase;glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N- acetylglucosaminyltransferase;glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase; 2.4.1.224; EXTL
• Gene ID: 2134
• mRNA Refseq: NM_004455.2
• Protein Refseq: NP_004446.2
• MIM: 601738
• UniProt ID: Q92935
• Chromosome Location: 1p36.1
• Pathway: Glycosaminoglycan biosynthesis - heparan sulfate, organism-specific biosystem; Glycosaminoglycan biosynthesis - heparan sulfate, conserved biosystem; Glycosaminoglycan biosynthesis, heparan sulfate backbone, organism-specific biosystem; Glycosaminoglycan biosynthesis, heparan sulfate backbone, conserved biosystem; heparan sulfate biosynthesis, organism-specific biosystem; heparan sulfate biosynthesis, conserved biosystem; heparan sulfate biosynthesis (late stages), organism-specific biosystem
• Function: glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity