Recombinant Human FBXL21, His-tagged

• Cat.No.: FBXL21-12779H
• Product Overview: Recombinant Human FBXL21 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 6 tandem leucine-rich repeats. The amino acid sequence of this protein is highly similar to that of f-box and leucine-rich repeat protein 3A. Comparisons of this gene to orthologous sequences suggest that it may be a pseudogene, and may no longer express a functional protein.
• Source: E.coli
• Species: Human
• Tag: His
• Protein length: C-term-214a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: FBXL21 F-box and leucine-rich repeat protein 21 (gene/pseudogene) [ Homo sapiens ]
• Official Symbol: FBXL21
• Synonyms: FBXL21; F-box and leucine-rich repeat protein 21 (gene/pseudogene); F box and leucine rich repeat protein 3 pseudogene , F box and leucine rich repeat protein 21 , FBXL3B, FBXL3P; F-box/LRR-repeat protein 21; F box and leucine rich repeat protein 3B; FBL3B; Fbl21; F-box protein Fbl3b; F-box/LRR-repeat protein 3B; F-box and leucine-rich repeat protein 3B; F-box and leucine-rich repeat protein 3 pseudogene; FBXL3B; FBXL3P; MGC120237
• Gene ID: 26223
• mRNA Refseq: NM_012159
• Protein Refseq: NP_036291
• MIM: 609087
• UniProt ID: Q9UKT6
• Chromosome Location: 5q31
• Function: ubiquitin-protein ligase activity