Recombinant Human FECH, His-tagged FECH-12837H

Recombinant Human FECH, His-tagged

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Recombinant Human FECH, His-tagged

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Cat.No. : FECH-12837H
Product Overview : Recombinant Human FECH protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Description : The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome 3.
Source : E.coli
Species : Human
Tag : His
Protein length : 60-423a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : FECH ferrochelatase [ Homo sapiens ]
Official Symbol : FECH
Synonyms : FECH; ferrochelatase; ferrochelatase (protoporphyria); ferrochelatase, mitochondrial; protoporphyria; heme synthase; heme synthetase; protoheme ferro-lyase; EPP; FCE;
Gene ID : 2235
mRNA Refseq : NM_000140
Protein Refseq : NP_000131
MIM : 612386
UniProt ID : P22830
Chromosome Location : 18q21.2-q21.3
Pathway : HIF-1-alpha transcription factor network, organism-specific biosystem; Heme Biosynthesis, organism-specific biosystem; Heme biosynthesis, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of porphyrins, organism-specific biosystem; Porphyrin and chlorophyll metabolism, organism-specific biosystem;
Function : 2 iron, 2 sulfur cluster binding; ferrochelatase activity; ferrochelatase activity; ferrous iron binding; metal ion binding; protein binding;

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