"FMO4" Related Products


Recombinant Human FMO4, GST-tagged

Cat.No.: FMO4-12945H
Product Overview: Recombinant Human FMO4 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description: Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.
Source: E.coli
Species: Human
Tag: GST
Protein length: 24-354a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name: FMO4 flavin containing monooxygenase 4 [ Homo sapiens ]
Official Symbol: FMO4
Synonyms: FMO4; flavin containing monooxygenase 4; FMO2; dimethylaniline monooxygenase [N-oxide-forming] 4; FMO 4; dimethylaniline oxidase 4; hepatic flavin-containing monooxygenase 4;
Gene ID: 2329
mRNA Refseq: NM_002022
Protein Refseq: NP_002013
MIM: 136131
UniProt ID: P31512
Chromosome Location: 1q24.3
Pathway: Drug metabolism - cytochrome P450, organism-specific biosystem; Drug metabolism - cytochrome P450, conserved biosystem; nicotine degradation II, organism-specific biosystem;
Function: N,N-dimethylaniline monooxygenase activity; NADP binding; flavin adenine dinucleotide binding; monooxygenase activity;

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