Recombinant Human GABRA1, GST-tagged
Cat.No. : | GABRA1-13092H |
Product Overview : | Recombinant Human GABRA1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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Description : | This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 20-260a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 [ Homo sapiens ] |
Official Symbol : | GABRA1 |
Synonyms : | GABRA1; gamma-aminobutyric acid (GABA) A receptor, alpha 1; gamma-aminobutyric acid receptor subunit alpha-1; EJM5; GABA(A) receptor; alpha 1; GABA(A) receptor, alpha 1; GABA(A) receptor subunit alpha-1; EJM; ECA4; |
Gene ID : | 2554 |
mRNA Refseq : | NM_000806 |
Protein Refseq : | NP_000797 |
MIM : | 137160 |
UniProt ID : | P14867 |
Chromosome Location : | 5q34 |
Pathway : | GABA A receptor activation, organism-specific biosystem; GABA receptor activation, organism-specific biosystem; GABAergic synapse, organism-specific biosystem; GABAergic synapse, conserved biosystem; Ion channel transport, organism-specific biosystem; Ligand-gated ion channel transport, organism-specific biosystem; Morphine addiction, organism-specific biosystem; |
Function : | GABA-A receptor activity; chloride channel activity; drug binding; extracellular ligand-gated ion channel activity; ion channel activity; receptor activity; |
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◆ Lysates | ||
GABRA1-6067HCL | Recombinant Human GABRA1 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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