Recombinant Human GABRE, His-tagged

• Cat.No.: GABRE-13101H
• Product Overview: Recombinant Human GABRE protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Description: The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants have been identified, but only one is thought to encode a protein.
• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 28-279a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon [ Homo sapiens ]
• Official Symbol: GABRE
• Synonyms: GABRE; gamma-aminobutyric acid (GABA) A receptor, epsilon; gamma-aminobutyric acid receptor subunit epsilon; GABA(A) receptor; epsilon; GABA(A) receptor, epsilon; GABA(A) receptor subunit epsilon
• Gene ID: 2564
• mRNA Refseq: NM_004961
• Protein Refseq: NP_004952
• MIM: 300093
• UniProt ID: P78334
• Chromosome Location: Xq28
• Pathway: GABAergic synapse, organism-specific biosystem; GABAergic synapse, conserved biosystem; Morphine addiction, organism-specific biosystem; Morphine addiction, conserved biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem; Nicotine addiction, organism-specific biosystem
• Function: GABA-A receptor activity; chloride channel activity; extracellular ligand-gated ion channel activity; ion channel activity