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Recombinant Human GSDMD protein, His-tagged

Cat.No. : GSDMD-13558H
Product Overview : Recombinant Human GSDMD protein(135-484 aa), fused with His tag, was expressed in E.coli.
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Source : E.coli
Species : Human
Tag : His
Form : The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH7.4). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization. The elution buffer contain 300mM imidazole.
Protein Length : 135-484 aa
AA Sequence : HERHLRQPEHKVLQQLRSRGDNVYV VTEVLQTQKEVEVTRTHKREGSGRF SLPGATCLQGEGQGHLSQKKTVTIP SGSTLAFRVAQLVIDSDLDVLLFPD KKQRTFQPPATGHKRSTSEGAWPQL PSGLSMMRCLHNFLTDGVPAEGAFT EDFQGLRAEVETISKELELLDRELC QLLLEGLEGVLRDQLALRALEEALE QGQSLGPVEPLDGPAGAVLECLVLS SGMLVPELAIPVVYLLGALTMLSET QHKLLAEALESQTLLGPLELVGSLL EQSAPWQERSTMSLPPGLLGNSWGE GAPAWVLLDECGLELGEDTPHVCWE PQAQGRMCALYASLALLSGLSQEPH
Purity : 85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
Storage : Short-term storage: Store at 2-8°C for (1-2 weeks).
Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles.
Reconstitution : Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage.
Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage.
Gene Name : GSDMD gasdermin D [ Homo sapiens ]
Official Symbol : GSDMD
Synonyms : GSDMD; gasdermin D; gasdermin domain containing 1 , GSDMDC1; gasdermin-D; DF5L; FLJ12150; gasdermin domain containing 1; gasdermin domain-containing protein 1; DFNA5L; FKSG10; GSDMDC1;
Gene ID : 79792
mRNA Refseq : NM_001166237
Protein Refseq : NP_001159709
UniProt ID : P57764

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Can GSDMD protein serve as a prognostic marker for patient outcomes in inflammatory diseases? 10/09/2021

Studies have suggested that the expression levels of GSDMD protein may be associated with disease severity and prognosis in certain inflammatory conditions, indicating its potential as a prognostic marker.

Can mutations in the GSDMD gene lead to clinical manifestations? 08/03/2021

Mutations in the GSDMD gene have been associated with autoinflammatory disorders, such as familial Mediterranean fever, which presents with recurrent episodes of fever and inflammation.

How is the activity of GSDMD protein regulated in the context of inflammatory diseases? 04/06/2018

Various signaling pathways and post-translational modifications regulate the activity of GSDMD protein, contributing to its involvement in the pathogenesis of inflammatory diseases.

How is the inflammasome linked to the function of GSDMD protein in clinical settings? 01/11/2017

The inflammasome, a multiprotein complex that regulates inflammatory responses, activates GSDMD protein to induce pyroptosis and release of pro-inflammatory cytokines, contributing to the pathogenesis of inflammatory diseases.

What are the potential diagnostic applications of targeting GSDMD protein? 04/24/2016

Targeting GSDMD protein could lead to the development of diagnostic tools for detecting and monitoring inflammatory diseases, providing valuable insights for patient management.

Customer Reviews (3)

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Reviews
06/18/2021

    Whether I need to study protein-protein interactions, protein localization, or protein folding, the GSDMD protein consistently delivers precise and meaningful data.

    07/27/2017

      the GSDMD protein's compatibility with various experimental techniques further supports its usability.

      01/19/2016

        One of the standout features of the GSDMD protein is the excellent technical support provided by the manufacturer.

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