Recombinant Human GTF2B, GST-tagged

• Cat.No.: GTF2B-13590H
• Product Overview: Recombinant Human GTF2B protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 1-316a.a.
• Description: Human glutamate receptor delta-2 (GRID2) is a relatively new member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. GRID2 is a predicted 1,007 amino acid protein that shares 97% identity with the mouse homolog which is expressed selectively in cerebellar Purkinje cells. A point mutation in mouse GRID2, associated with the phenotype named lurcher, in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This strongly suggests a role for GRID2 in neuronal apoptotic death.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: GTF2B general transcription factor IIB [ Homo sapiens ]
• Official Symbol: GTF2B
• Synonyms: GTF2B; general transcription factor IIB; transcription initiation factor IIB; TFIIB; S300-II; general transcription factor TFIIB; RNA polymerase II transcription factor IIB; TF2B
• Gene ID: 2959
• mRNA Refseq: NM_001514
• Protein Refseq: NP_001505
• MIM: 189963
• UniProt ID: Q00403
• Chromosome Location: 1p22-p21
• Pathway: Basal transcription factors, organism-specific biosystem; Basal transcription factors, conserved biosystem; Disease, organism-specific biosystem; Eukaryotic Transcription Initiation, organism-specific biosystem; Gene Expression, organism-specific biosystem; HIV Infection, organism-specific biosystem; HIV Life Cycle, organism-specific biosystem
• Function: DNA binding; metal ion binding; protein binding; thyroid hormone receptor binding; transcription factor binding; translation initiation factor activity; zinc ion binding