Recombinant Human GUCY1B3, His-tagged

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Recombinant Human GUCY1B3, His-tagged

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Cat.No. : GUCY1B3-13619H
Product Overview : Recombinant Human GUCY1B3 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Description : Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha subunit and a beta subunit, typically GUCY1B3, catalyzes conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide (NO) and nitrovasodilator drugs (Zabel et al., 1998 [PubMed 9742212]).
Source : E.coli
Species : Human
Tag : His
Protein length : 282-619a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : GUCY1B3 guanylate cyclase 1, soluble, beta 3 [ Homo sapiens ]
Official Symbol : GUCY1B3
Synonyms : GUCY1B3; guanylate cyclase 1, soluble, beta 3; GUC1B3; guanylate cyclase soluble subunit beta-1; GC S beta 1; GC SB3; GCS-beta-1; GCS-beta-3; soluble guanylate cyclase small subunit; guanylate cyclase soluble subunit beta-3; GUCB3; GC-SB3; GUCSB3; GUCY1B1; GC-S-beta-1;
Gene ID : 2983
mRNA Refseq : NM_000857
Protein Refseq : NP_000848
MIM : 139397
UniProt ID : Q02153
Chromosome Location : 4q31.3-q33
Pathway : Gap junction, organism-specific biosystem; Gap junction, conserved biosystem; Hemostasis, organism-specific biosystem; Long-term depression, organism-specific biosystem; Long-term depression, conserved biosystem; Nitric oxide stimulates guanylate cyclase, organism-specific biosystem; Platelet homeostasis, organism-specific biosystem;
Function : GTP binding; Hsp90 protein binding; guanylate cyclase activity; heme binding; ion binding; metal ion binding; nucleotide binding; protein heterodimerization activity; receptor activity;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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