"HLA-DOB" Related Products

Recombinant Human HLA-DOB, GST-tagged

Cat.No.: HLA-DOB-13815H
Product Overview: Recombinant Human HLA-DOB protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description: HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
Source: E.coli
Species: Human
Tag: GST
Protein length: 1-99a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name: HLA-DOB major histocompatibility complex, class II, DO beta [ Homo sapiens ]
Official Symbol: HLA-DOB
Synonyms: HLA-DOB; major histocompatibility complex, class II, DO beta; HLA class II histocompatibility antigen, DO beta chain; MHC class II antigen DOB; DOB; FLJ57033;
Gene ID: 3112
mRNA Refseq: NM_002120
Protein Refseq: NP_002111
MIM: 600629
UniProt ID: P13765
Chromosome Location: 6p21.3
Pathway: Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem;
Function: MHC class II receptor activity;

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