Recombinant Human HMGCL, His-tagged
Cat.No. : | HMGCL-13845H |
Product Overview : | Recombinant Human HMGCL protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose. |
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Description : | The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Protein length : | 1-325a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol. |
Gene Name : | HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase [ Homo sapiens ] |
Official Symbol : | HMGCL |
Synonyms : | HMGCL; 3-hydroxymethyl-3-methylglutaryl-CoA lyase; 3 hydroxymethyl 3 methylglutaryl Coenzyme A lyase; hydroxymethylglutaryl-CoA lyase, mitochondrial; HL; hydroxymethylglutaricaciduria; HMG-CoA lyase; 3-hydroxy-3-methylglutaryl-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase; 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase; mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase; |
Gene ID : | 3155 |
mRNA Refseq : | NM_000191 |
Protein Refseq : | NP_000182 |
MIM : | 613898 |
UniProt ID : | P35914 |
Chromosome Location : | 1p36.1-p35 |
Pathway : | Butanoate metabolism, organism-specific biosystem; Butanoate metabolism, conserved biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Ketone body metabolism, organism-specific biosystem; Leucine degradation, leucine => acetoacetate + acetyl-CoA, organism-specific biosystem; Leucine degradation, leucine => |
Function : | carboxylic acid binding; fatty-acyl-CoA binding; hydroxymethylglutaryl-CoA lyase activity; hydroxymethylglutaryl-CoA lyase activity; lyase activity; magnesium ion binding; manganese ion binding; metal ion binding; protein homodimerization activity; |
Products Types
◆ Recombinant Protein | ||
HMGCL-211H | Recombinant Human HMGCL Protein, His-tagged | +Inquiry |
HMGCL-336C | Recombinant Cynomolgus Monkey HMGCL Protein, His (Fc)-Avi-tagged | +Inquiry |
Hmgcl-1136M | Recombinant Mouse Hmgcl Protein, MYC/DDK-tagged | +Inquiry |
HMGCL-2522R | Recombinant Rat HMGCL Protein, His (Fc)-Avi-tagged | +Inquiry |
HMGCL-4239M | Recombinant Mouse HMGCL Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
HMGCL-5475HCL | Recombinant Human HMGCL 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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