Recombinant Human HOMER3, His-tagged

• Cat.No.: HOMER3-13881H
• Product Overview: Recombinant Human HOMER3 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Description: This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.
• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 1-361a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: HOMER3 homer homolog 3 (Drosophila) [ Homo sapiens ]
• Official Symbol: HOMER3
• Synonyms: HOMER3; homer homolog 3 (Drosophila); homer protein homolog 3; HOMER 3; Homer, neuronal immediate early gene, 3; VESL3; HOMER-3
• Gene ID: 9454
• mRNA Refseq: NM_001145721
• Protein Refseq: NP_001139193
• MIM: 604800
• UniProt ID: Q9NSC5
• Chromosome Location: 19p13.1
• Pathway: Glutamatergic synapse, organism-specific biosystem; Glutamatergic synapse, conserved biosystem; T Cell Receptor Signaling Pathway, organism-specific biosystem
• Function: protein C-terminus binding; protein binding; protein domain specific binding