"METAP2" Related Products

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Recombinant Human METAP2, His-tagged

Cat. No.: METAP2-635H
Product Overview: Recombinant Human METAP2 (Ala2-Tyr478) fused with 10­His tag at C­terminal, was expressed in Spodoptera frugiperda.
Description: This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2.
Source: Spodoptera frugiperda
Molecular Mass: 54 kDa
N-terminal SequenceAnalysis: Ala2
Formulation: Supplied as a 0.2 µm filtered solution in Tris, NaCl and Glycerol.
Purity: >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Activity: Measure by its ability to remove methionine from a fluorogenic peptide substrate H-Met-Gly-Pro-AMC. The resulting GP-AMC is cleaved by Recombinant Human DPPIV/CD26. The specific activity is >15 pmol/min/µg, as measured using the described conditions.
EndotoxinLevel: <1.0 EU per 1 μg of the protein by the LAL method.
Storage: 6 months from date of receipt, ­70 °C as supplied. Avoid repeated freeze­thaw cycles.
OfficialSymbol: METAP2
Gene Name: METAP2 methionyl aminopeptidase 2 [ Homo sapiens ]
Synonyms: METAP2; methionyl aminopeptidase 2; MAP 2; Peptidase M; eIF-2-associated p67 homolog; initiation factor 2-associated 67 kDa glycoprotein; metAP 2; methionine aminopeptidase 2; peptidase M 2; p67; MAP2; MNPEP; p67eIF2; EC 3.4.11.18
Gene ID: 10988
mRNA Refseq: NM_006838
Protein Refseq: NP_006829
MIM: 601870
UniProt ID: P50579
Chromosome Location: 12q22
Function: aminopeptidase activity; metal ion binding; metalloexopeptidase activity

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