"METAP2" Related Products

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Recombinant Human METAP2, His-tagged

Cat. No. : METAP2-635H
Product Overview : Recombinant Human METAP2 (Ala2-Tyr478) fused with 10­His tag at C­terminal, was expressed in Spodoptera frugiperda.
Description : This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2.
Source : Spodoptera frugiperda
Molecular Mass : 54 kDa
N-terminal SequenceAnalysis : Ala2
Formulation : Supplied as a 0.2 µm filtered solution in Tris, NaCl and Glycerol.
Purity : >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Activity : Measure by its ability to remove methionine from a fluorogenic peptide substrate H-Met-Gly-Pro-AMC. The resulting GP-AMC is cleaved by Recombinant Human DPPIV/CD26. The specific activity is >15 pmol/min/µg, as measured using the described conditions.
EndotoxinLevel : <1.0 EU per 1 μg of the protein by the LAL method.
Storage : 6 months from date of receipt, ­70 °C as supplied. Avoid repeated freeze­thaw cycles.
OfficialSymbol : METAP2
PDB rendering basedon 1b59. :

Gene Name : METAP2 methionyl aminopeptidase 2 [ Homo sapiens ]
Synonyms : METAP2; methionyl aminopeptidase 2; MAP 2; Peptidase M; eIF-2-associated p67 homolog; initiation factor 2-associated 67 kDa glycoprotein; metAP 2; methionine aminopeptidase 2; peptidase M 2; p67; MAP2; MNPEP; p67eIF2; EC 3.4.11.18
Gene ID : 10988
mRNA Refseq : NM_006838
Protein Refseq : NP_006829
MIM : 601870
UniProt ID : P50579
Chromosome Location : 12q22
Function : aminopeptidase activity; metal ion binding; metalloexopeptidase activity

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