Recombinant Human ZNF346, His-tagged

• Cat.No.: ZNF346-2306H
• Product Overview: Recombinant human ZNF346 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Description: ZNF346 is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. ZNF346 may be involved in cell growth and survival.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 2mM DTT
• Molecular Mass: 35.3 kDa
• Protein length: 317aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMEYPAPA TVQAADGGAA GPYSSSELLE GQEPDGVRFD RERARRLWEA VSGAQPVGRE EVEHMIQKNQCLFTNTQCKV CCALLISESQ KLAHYQSKKH ANKVKRYLAI HGMETLKGET KKLDSDQKSS RSKDKNQCCP ICNMTFSSPV VAQSHYLGKT HAKNLKLKQQ STKVEALHQN REMIDPDKFC SLCHATFNDP VMAQQHYVGK KHRKQETKLK LMARYGRLAD PAVTDFPAGK GYPCKTCKIVLNSIEQYQAH VSGFKHKNQS PKTVASSLGQ IPMQRQPIQK DSTTLED
• Purity: >90% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25 mg/ml

Gene Information

• Gene Name: ZNF346 zinc finger protein 346 [ Homo sapiens ]
• Official Symbol: ZNF346
• Synonyms: ZNF346; zinc finger protein 346; JAZ; Zfp346; just another zinc finger protein; double-stranded RNA-binding zinc finger protein JAZ; DKFZp547M223
• Gene ID: 23567
• mRNA Refseq: NM_012279
• Protein Refseq: NP_036411
• MIM: 605308
• UniProt ID: Q9UL40
• Chromosome Location: 5q35.3
• Function: double-stranded RNA binding; metal ion binding; zinc ion binding