Active Recombinant Human VEGFA
Cat.No. : | VEGFA-8699H |
Product Overview : | Recombinant human Vascular Endothelial Growth Factor A165 (rhVEGF-A165) produced in Pichia pastoris is a disulfide-linked homodimer containing two polypeptide chains of 165 amino acids each. |
- Specification
- Gene Information
- Related Products
Description : | Vascular Endothelial Growth Factor (VEGF) is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, Vascular Endothelial Growth Factor (VEGF) plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates Vascular Endothelial Growth Factor (VEGF) in the induction of tumor metastasis and intra-ocular neovascular syndromes. Vascular Endothelial Growth Factor (VEGF) signals through the three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. |
Source : | Pichia pastoris |
Species : | Human |
Form : | Lyophilized after extensive dialysis against 25 mM HEPES and 150 mM NaCl, pH 7.0. |
Bio-activity : | ED50 of 1-5ng/ml, measured by the dose-dependent stimulation of the proliferation of HUVEC cells, corresponding to a specific activity of 2x 105-1x 106 units/mg. |
Molecular Mass : | 38.2kDa, observed by non-reducing SDS-PAGE |
AA Sequence : | Ala27-Arg191. |
Endotoxin : | <0.5 eu/μg, determined by lal>0.5> |
Purity : | >95% as analyzed by reducing SDS-PAGE. |
Storage : | Lyophilized recombinant protein remains stable up to 12 months at -80°C from date of receipt. Upon reconstitution, rhVEGF-A165 should be stable up to 4 week at 4°C or up to 6 months at -20°C. |
Reconstitution : | Reconstituted in ddH2O at 100 μg/ml. |
Gene Name : | VEGFA vascular endothelial growth factor A [ Homo sapiens ] |
Official Symbol : | VEGFA |
Synonyms : | VEGFA; vascular endothelial growth factor A; vascular endothelial growth factor , VEGF; VEGF A; VPF; vascular permeability factor; VEGF; MVCD1; MGC70609; |
Gene ID : | 7422 |
mRNA Refseq : | NM_001025366 |
Protein Refseq : | NP_001020537 |
UniProt ID : | P15692 |
Chromosome Location : | 6p12 |
Pathway : | Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Endochondral Ossification, organism-specific biosystem; Focal adhesion, organism-specific biosystem; Focal adhesion, conserved biosystem; |
Function : | cell surface binding; chemoattractant activity; cytokine activity; cytokine activity; extracellular matrix binding; fibronectin binding; growth factor activity; growth factor activity; heparin binding; heparin binding; platelet-derived growth factor receptor binding; protein binding; protein heterodimerization activity; protein homodimerization activity; receptor agonist activity; vascular endothelial growth factor receptor 1 binding; vascular endothelial growth factor receptor 2 binding; vascular endothelial growth factor receptor binding; |
Products Types
◆ Recombinant Protein | ||
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VEGFA-52H | Active Recombinant Human VEGFA-163 Protein, Animal Free | +Inquiry |
VEGFA-106H | Active Recombinant Human VEGFA Protein | +Inquiry |
VEGFA-5529H | Recombinant Human Vascular Endothelial Growth Factor A | +Inquiry |
◆ Lysates | ||
VEGFA-974HCL | Recombinant Human VEGFA cell lysate | +Inquiry |
VEGFA-655HCL | Recombinant Human VEGFA cell lysate | +Inquiry |
VEGFA-647MCL | Recombinant Mouse VEGFA cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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