Recombinant Human HDAC3, His-tagged HDAC3-390H

Recombinant Human HDAC3, His-tagged

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Recombinant Human HDAC3, His-tagged

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Cat.No. : HDAC3-390H
Product Overview : Recombinant Human HDAC3 was expressed in insect cell.
Description : Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Source : insect cells
Species : Human
Tag : His
Form : 103 μg/μl in 50 mM Tris, pH 8.0, 138 mM NaCl and 10% glycerol.
Specific activity : >1 U/µg.
Molecular Mass : 49 kDa
Protein length : 428 amino acids
Purity : ~50% by SDS-PAGE.
Applications : Study HDAC3 kinetics and inhibitor sensitivity and also the effect of the enzyme in transcriptional regulation, cell cycle progression, and oncogenesis.
Gene Name : HDAC3 histone deacetylase 3 [ Homo sapiens (human) ]
Official Symbol : HDAC3
Synonyms : HDAC3; histone deacetylase 3; HD3; RPD3; RPD3-2; histone deacetylase 3; SMAP45; EC 3.5.1.98
Gene ID : 8841
mRNA Refseq : NM_003883
Protein Refseq : NP_003874
MIM : 605166
UniProt ID : O15379
Chromosome Location : 5q31
Pathway : Alcoholism; BMAL1:CLOCK/NPAS2 Activates Circadian Expression; Cell cycle; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Function : chromatin DNA binding; enzyme binding; histone deacetylase activity; protein binding

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