"HDAC3" Related Products

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Recombinant Human HDAC3, His-tagged

Cat.No.: HDAC3-390H
Product Overview: Recombinant Human HDAC3 was expressed in insect cell.
Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Source: insect cells
Species: Human
Tag: His
Form: 103 μg/μl in 50 mM Tris, pH 8.0, 138 mM NaCl and 10% glycerol.
Specific activity: >1 U/µg.
Molecular Mass: 49 kDa
Protein length: 428 amino acids
Purity: ~50% by SDS-PAGE.
Applications: Study HDAC3 kinetics and inhibitor sensitivity and also the effect of the enzyme in transcriptional regulation, cell cycle progression, and oncogenesis.
Gene Name: HDAC3 histone deacetylase 3 [ Homo sapiens (human) ]
Official Symbol: HDAC3
Synonyms: HDAC3; histone deacetylase 3; HD3; RPD3; RPD3-2; histone deacetylase 3; SMAP45; EC 3.5.1.98
Gene ID: 8841
mRNA Refseq: NM_003883
Protein Refseq: NP_003874
MIM: 605166
UniProt ID: O15379
Chromosome Location: 5q31
Pathway: Alcoholism; BMAL1:CLOCK/NPAS2 Activates Circadian Expression; Cell cycle; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Function: chromatin DNA binding; enzyme binding; histone deacetylase activity; protein binding

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