"IL28B" Related Products

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Recombinant Human IL28B

Cat.No. : IL28B-605H
Product Overview : Interleukin-28B Human Recombinant produced in HEK cells is a non-glycosylated monomer, having a total molecular weight of 24kDa. The IL28B is purified by proprietary chromatographic techniques.
Description : This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
Source : HEK cells
Species : Human
Formulation : The IL28B was lyophilized from 1mg/ml in 1xPBS.
Bio-activity : The specific activity was determined by the dose dependent protection of the cytopathic effect on A549 cells (human lung adenocarcinoma epithelial cell line) that were challenged with encephalomyocarditis (EMC) virus and is typically 0.1-1ng/ml.
Molecular Mass : 24 kDa
Physical Appearence : Sterile Filtered White lyophilized (freeze-dried) powder.
Purity : Greater than 95% as obsereved by SDS-PAGE.
Solubility : It is recommended to reconstitute the lyophilized IL-28B in sterile water not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Gene Name : IFNL3 interferon, lambda 3 [ Homo sapiens (human) ]
Official Symbol : IFNL3
Synonyms : IFNL3; IL28B; IL28C; IL-28B; interferon, lambda 3; interferon lambda-3; IL-28C; IFN-lambda-3; IFN-lambda-4; interleukin 28C; interleukin-28B; interleukin-28C; cytokine Zcyto22; interferon lambda-4; interferon, lambda 4; interleukin 28B (interferon, lambda 3)
Gene ID : 282617
mRNA Refseq : NM_172139
Protein Refseq : NP_742151
MIM : 607402
UniProt ID : Q8IZI9
Chromosome Location : 19q13.13
Pathway : Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Type III interferon signaling
Function : cytokine activity

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