Active Recombinant Human IL28B

• Cat.No.: IL28B-605H
• Product Overview: Interleukin-28B Human Recombinant produced in HEK cells is a non-glycosylated monomer, having a total molecular weight of 24kDa. The IL28B is purified by proprietary chromatographic techniques.

Specification

• Description: This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
• Source: HEK cells
• Species: Human
• Formulation: The IL28B was lyophilized from 1mg/ml in 1xPBS.
• Bio-activity: The specific activity was determined by the dose dependent protection of the cytopathic effect on A549 cells (human lung adenocarcinoma epithelial cell line) that were challenged with encephalomyocarditis (EMC) virus and is typically 0.1-1ng/ml.
• Molecular Mass: 24 kDa
• Physical Appearence: Sterile Filtered White lyophilized (freeze-dried) powder.
• Purity: Greater than 95% as obsereved by SDS-PAGE.
• Solubility: It is recommended to reconstitute the lyophilized IL-28B in sterile water not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Gene Information

• Gene Name: IFNL3 interferon, lambda 3 [ Homo sapiens (human) ]
• Official Symbol: IFNL3
• Synonyms: IFNL3; IL28B; IL28C; IL-28B; interferon, lambda 3; interferon lambda-3; IL-28C; IFN-lambda-3; IFN-lambda-4; interleukin 28C; interleukin-28B; interleukin-28C; cytokine Zcyto22; interferon lambda-4; interferon, lambda 4; interleukin 28B (interferon, lambda 3)
• Gene ID: 282617
• mRNA Refseq: NM_172139
• Protein Refseq: NP_742151
• MIM: 607402
• UniProt ID: Q8IZI9
• Chromosome Location: 19q13.13
• Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Type III interferon signaling
• Function: cytokine activity