Recombinant human SLA2, His-tagged

• Cat.No.: SLA2-2474H
• Product Overview: Recombinant human SLA2 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Specification

• Description: SLA2 is a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene.
• Source: E.coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M Urea
• Molecular Mass: 31.0kDa (284aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMGSLPSR RKSLPSPSLS SSVQGQGPVT MEAERSKATA VALGSFPAGG PAELSLRLGE PLTIVSEDGDWWTVLSEVSG REYNIPSVHV AKVSHGWLYE GLSREKAEEL LLLPGNPGGA FLIRESQTRR GSYSLSVRLS RPASWDRIRH YRIHCLDNGW LYISPRLTFP SLQALVDHYS ELADDICCLL KEPCVLQRAG PLPGKDIPLP VTVQRTPLNW KELDSSLLFS EAATGEESLL SEGLRESLSFYISLNDEAVS LDDA
• Purity: >80 % by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: SLA2 Src-like-adaptor 2 [ Homo sapiens ]
• Official Symbol: SLA2
• Synonyms: SLA2; Src-like-adaptor 2; C20orf156; src-like-adapter 2; FLJ21992; SLAP 2; Src-like adapter protein-2; modulator of antigen receptor signaling; MARS; SLAP2; SLAP-2; MGC49845
• Gene ID: 84174
• mRNA Refseq: NM_032214
• Protein Refseq: NP_115590
• MIM: 606577
• UniProt ID: Q9H6Q3
• Chromosome Location: 20q11.23
• Pathway: B Cell Receptor Signaling Pathway, organism-specific biosystem; T Cell Receptor Signaling Pathway, organism-specific biosystem; TCR signaling in naive CD4+ T cells, organism-specific biosystem
• Function: SH3/SH2 adaptor activity; protein N-terminus binding; protein binding