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Recombinant Human DUSP4, GST-tagged

Cat.No. : DUSP4-101H
Product Overview : Human DUSP4 full-length ORF ( AAH02671, 1 a.a. - 394 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.
Source : Wheat germ
Species : Human
Tag : GST
Molecular Mass : 69.08 kDa
AA Sequence : MVTMEELREMDCSVLKRLMNRDENG GGAGGSGSHGTLGLPSGGKCLLLDC RPFLAHSAGYILGSVNVRCNTIVRR RAKGSVSLEQILPAEEEVRARLRSG LYSAVIVYDERSPRAESLREDSTVS LVVQALRRNAERTDICLLKGGYERF SSEYPEFCSKTKALAAIPPPVPPSA TEPLDLGCSSCGTPLHDQGGPVEIL PFLYLGSAYHAARRDMLDALGITAL LNVSSDCPNHFEGHYQYKCIPVEDN HKADISSWFMEAIEYIDAVKDCRGR VLVHCQAGISRSATICLAYLMMKKR VRLEEAFEFVKQRRSIISPNFSFMG QLLQFESQVLATSCAAEAASPSGPL RERGKTPATPTSQFVFSFPVSVGVH SAPSSLPYLHSPITTSPSC
Applications : ELISA; WB; Antibody Production; Protein Array
Storage : Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : DUSP4 dual specificity phosphatase 4 [ Homo sapiens (human) ]
Official Symbol : DUSP4
Synonyms : DUSP4; TYP; HVH2; MKP2; MKP-2; dual specificity phosphatase 4; MAP kinase phosphatase 2; VH1 homologous phosphatase 2; dual specificity protein phosphatase hVH2; serine/threonine specific protein phosphatase; mitogen-activated protein kinase phosphatase 2; EC 3.1.3.16; EC 3.1.3.48
Gene ID : 1846
mRNA Refseq : NM_001394
Protein Refseq : NP_001385
MIM : 602747
UniProt ID : Q13115
Chromosome Location : 8p12-p11
Pathway : Activated TLR4 signalling; B Cell Receptor Signaling Pathway; ERK/MAPK targets
Function : MAP kinase tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/threonine phosphatase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is DUSP4 involved in the signaling pathway? 08/16/2022

DUSP4 inactivates MAPKs by dephosphorylating them and thus performs an important function in the MAPK signaling pathway

What is DUSP4 also known as? 01/08/2022

DUSP4 also known as mitogen-activated protein kinase phosphatase 2

Which membrane is recommended for DUSP4 protein for WB? 04/01/2021

You can choose PVDF membrane.

What diseases is DUSP4 involved in? 03/01/2021

DUSP4 is involved in diseases such as laryngeal, breast and colorectal cancer

What are the effects of overexpression of DUSP4? 10/19/2020

In colon cancer, overexpression of DUSP4 may lead to increased proliferation of tumor cells through stimulation of growth-promoting genes such as Myc and cell cycle protein D1

Customer Reviews (3)

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Reviews
08/16/2022

    The protein composition was stable and concentrated, allowing me to obtain satisfactory experimental results.

    07/21/2022

      Very good after-sales service to get my experiments going!

      02/04/2022

        The technician modified my experimental protocol so that my experiment went smoothly.

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