Recombinant Human DUSP4, GST-tagged
Cat.No. : | DUSP4-101H |
Product Overview : | Human DUSP4 full-length ORF ( AAH02671, 1 a.a. - 394 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. |
Source : | Wheat germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 69.08 kDa |
AA Sequence : | MVTMEELREMDCSVLKRLMNRDENG GGAGGSGSHGTLGLPSGGKCLLLDC RPFLAHSAGYILGSVNVRCNTIVRR RAKGSVSLEQILPAEEEVRARLRSG LYSAVIVYDERSPRAESLREDSTVS LVVQALRRNAERTDICLLKGGYERF SSEYPEFCSKTKALAAIPPPVPPSA TEPLDLGCSSCGTPLHDQGGPVEIL PFLYLGSAYHAARRDMLDALGITAL LNVSSDCPNHFEGHYQYKCIPVEDN HKADISSWFMEAIEYIDAVKDCRGR VLVHCQAGISRSATICLAYLMMKKR VRLEEAFEFVKQRRSIISPNFSFMG QLLQFESQVLATSCAAEAASPSGPL RERGKTPATPTSQFVFSFPVSVGVH SAPSSLPYLHSPITTSPSC |
Applications : | ELISA; WB; Antibody Production; Protein Array |
Storage : | Store at -80°C. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | DUSP4 dual specificity phosphatase 4 [ Homo sapiens (human) ] |
Official Symbol : | DUSP4 |
Synonyms : | DUSP4; TYP; HVH2; MKP2; MKP-2; dual specificity phosphatase 4; MAP kinase phosphatase 2; VH1 homologous phosphatase 2; dual specificity protein phosphatase hVH2; serine/threonine specific protein phosphatase; mitogen-activated protein kinase phosphatase 2; EC 3.1.3.16; EC 3.1.3.48 |
Gene ID : | 1846 |
mRNA Refseq : | NM_001394 |
Protein Refseq : | NP_001385 |
MIM : | 602747 |
UniProt ID : | Q13115 |
Chromosome Location : | 8p12-p11 |
Pathway : | Activated TLR4 signalling; B Cell Receptor Signaling Pathway; ERK/MAPK targets |
Function : | MAP kinase tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/threonine phosphatase activity |
Products Types
◆ Recombinant Protein | ||
DUSP4-106H | Active Recombinant Human DUSP4 Protein, His-tagged | +Inquiry |
DUSP4-2572M | Recombinant Mouse DUSP4 Protein, His (Fc)-Avi-tagged | +Inquiry |
Dusp4-2690M | Recombinant Mouse Dusp4 Protein, Myc/DDK-tagged | +Inquiry |
DUSP4-105H | Recombinant Human DUSP4 Protein, Myc/DDK-tagged | +Inquiry |
DUSP4-1635R | Recombinant Rat DUSP4 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
DUSP4-6773HCL | Recombinant Human DUSP4 293 Cell Lysate | +Inquiry |
DUSP4-6774HCL | Recombinant Human DUSP4 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionDUSP4 inactivates MAPKs by dephosphorylating them and thus performs an important function in the MAPK signaling pathway
DUSP4 also known as mitogen-activated protein kinase phosphatase 2
You can choose PVDF membrane.
DUSP4 is involved in diseases such as laryngeal, breast and colorectal cancer
In colon cancer, overexpression of DUSP4 may lead to increased proliferation of tumor cells through stimulation of growth-promoting genes such as Myc and cell cycle protein D1
Customer Reviews (3)
Write a reviewThe protein composition was stable and concentrated, allowing me to obtain satisfactory experimental results.
Very good after-sales service to get my experiments going!
The technician modified my experimental protocol so that my experiment went smoothly.
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