Recombinant Human CYP2C19, MYC/DDK-tagged CYP2C19-538H

Recombinant Human CYP2C19, MYC/DDK-tagged

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Recombinant Human CYP2C19, MYC/DDK-tagged

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Cat.No. : CYP2C19-538H
Product Overview : Recombinant Human CYP2C19 fused with C-terminal MYC/DDK, was expressed in HEK293 Cells.
Description : This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.
Source : HEK293 Cells
Species : Human
Tag : MYC/DDK
Molecular Mass : 55.8 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Storage : Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
Concentration : >50 ug/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens (human) ]
Official Symbol : CYP2C19
Synonyms : CYP2C19; CPCJ; CYP2C; P450C2C; P450IIC19; cytochrome P450, family 2, subfamily C, polypeptide 19; cytochrome P450 2C19; CYPIIC17; CYPIIC19; cytochrome P450-11A; cytochrome P450-254C; cytochrome P-450 II C; microsomal monooxygenase; xenobiotic monooxygenase; mephenytoin 4-hydroxylase; mephenytoin 4''-hydroxylase; S-mephenytoin 4-hydroxylase; (R)-limonene 6-monooxygenase; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19; EC 1.14.13.48; EC 1.14.13.49
Gene ID : 1557
mRNA Refseq : NM_000769
Protein Refseq : NP_000760
MIM : 124020
UniProt ID : P33261
Chromosome Location : 10q24
Pathway : Arachidonic acid metabolism; Biological oxidations; Chemical carcinogenesis
Function : (R)-limonene 6-monooxygenase activity; (S)-limonene 7-monooxygenase activity; iron ion binding

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