Recombinant Human MAN1B1, His-tagged
Cat.No. : | MAN1B1-135H |
Product Overview : | Recombinant Human Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase/MAN1B1 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Asp106-Ala699) of Human MAN1B1 fused with a polyhistidine tag at the C-terminus. |
- Specification
- Gene Information
- Related Products
Description : | Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
AA Sequence : | DHWKALAFRLEEEQKMRPEIAGLKP ANPPVLPAPQKADTDPENLPEISSQ KTQRHIQRGPPHLQI RPPSQDLKDGTQEEATKRQEAPVDP RPEGDPQRTVISWRGAVIEPEQGTE LPSRRAEVPTKPPLP PARTQGTPVHLNYRQKGVIDVFLHA WKGYRKFAWGHDELKPVSRSFSEWF GLGLTLIDALDTMWI LGLRKEFEEARKWVSKKLHFEKDVD VNLFESTIRILGGLLSAYHLSGDSL FLRKAEDFGNRLMPA FRTPSKIPYSDVNIGTGVAHPPRWT SDSTVAEVTSIQLEFRELSRLTGDK KFQEAVEKVTQHIHG LSGKKDGLVPMFINTHSGLFTHLGV FTLGARADSYYEYLLKQWIQGGKQE TQLLEDYVEAIEGVR THLLRHSEPSKLTFVGELAHGRFSA KMDHLVCFLPGTLALGVYHGLPASH MELAQELMETCYQMN RQMETGLSPEIVHFNLYPQPGRRDV EVKPADRHNLLRPETVESLFYLYRV TGDRKYQDWGWEILQ SFSRFTRVPSGGYSSINNVQDPQKP EPRDKMESFFLGETLKYLFLLFSDD PNLLSLDAYVFNTEA HPLPIWTPAVDHHHHHH |
Endotoxin : | Less than 0.1 ng/μg (1 IEU/μg). |
Purity : | Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. |
Gene Name : | MAN1B1 mannosidase, alpha, class 1B, member 1 [ Homo sapiens ] |
Official Symbol : | MAN1B1 |
Synonyms : | MAN1B1; mannosidase, alpha, class 1B, member 1; endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; alpha 1; 2 mannosidase; endoplasmic reticulum alpha mannosidase 1; endoplasmic reticulum mannosyl oligosaccharide 1; 2 alpha mannosidase 1; ER alpha 1; Man9GlcNAc2 specific processing alpha mannosidase; MANA ER; ER alpha 1,2-mannosidase; Man9GlcNAc2-specific processing alpha-mannosidase; endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase 1; MRT15; ERMAN1; MANA-ER; FLJ37559; |
Gene ID : | 11253 |
mRNA Refseq : | NM_016219 |
Protein Refseq : | NP_057303 |
MIM : | 604346 |
UniProt ID : | Q9UKM7 |
Chromosome Location : | 9q34.3 |
Pathway : | Asparagine N-linked glycosylation, organism-specific biosystem; Calnexin/calreticulin cycle, organism-specific biosystem; ER Quality Control Compartment (ERQC), organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; N-Glycan biosynthesis, organism-specific biosystem; N-Glycan biosynthesis, conserved biosystem; |
Function : | calcium ion binding; hydrolase activity, acting on glycosyl bonds; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; |
Products Types
◆ Recombinant Protein | ||
MAN1B1-3206R | Recombinant Rat MAN1B1 Protein, His (Fc)-Avi-tagged | +Inquiry |
MAN1B1-5314M | Recombinant Mouse MAN1B1 Protein, His (Fc)-Avi-tagged | +Inquiry |
MAN1B1-3972H | Recombinant Human MAN1B1 Protein (Asp106-Ala699), C-His tagged | +Inquiry |
MAN1B1-3550R | Recombinant Rat MAN1B1 Protein | +Inquiry |
MAN1B1-9482M | Recombinant Mouse MAN1B1 Protein | +Inquiry |
◆ Lysates | ||
MAN1B1-4526HCL | Recombinant Human MAN1B1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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