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Recombinant Mouse Cxcl14 protein

Cat.No. : Cxcl14-614M
Product Overview : Recombinant Mouse Cxcl14 protein was expressed in Escherichia coli.
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  • Gene Information
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Description : Chemokine (C-X-C motif) ligand 14 (CXCL14), also named BRAK, is a small cytokine belonging to the CXC chemokine family. It is constitutively expressed at the mRNA level in certain normal tissues and it possesses chemoattractive activity for activated macrophages, immature dendritic cells and natural killer cells. According to the relevant literature, CXCL14 is associated with tumor development. Moreover, recent evidence revealed that CXCL14 participates in glucose metabolism, feeding behaviour-associated neuronal circuits, and anti-microbial defense. Although CXCL14 receptors have not yet been identified, the intracellular activity of CXCL14 in breast cancer cells suggests that the CXCL14 receptor(s) and signal transduction pathway(s) may be different from those of conventional CXC-type chemokines. Recombinant murine CXCL14 contains 77 amino acid residues and it shares 97 % and 99 % a.a. sequence identity with human and rat CXCL14.
Source : E.coli
Species : Mouse
Form : Lyophilized from a 0.2μm filtered concentrated solution in 20 mM PB, 400 mM NaCl, pH 7.4, 5 % trehalose.
Bio-activity : Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 1.0-10 ng/ml.
Molecular Mass : Approximately 9.4 kDa, a single non-glycosylated polypeptide chain containing 77amino acids.
Protein length : 77
AA Sequence : SKCKCSRKGPKIRYSDVKKLEMKPK YPHCEEKMVIVTTKSMSRYRGQEHC LHPKLQSTKRFIKWYNAWNEKRRVY EE
Endotoxin : Less than 1 EU/μg of rMuBRAK/CXCL14 as determined by LAL method.
Purity : >95% by SDS-PAGE and HPLC analysis.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions.
Gene Name : Cxcl14
Official Symbol : Cxcl14
Synonyms : CXCL14; chemokine (C-X-C motif) ligand 14; C-X-C motif chemokine 14; chemokine BRAK; small-inducible cytokine B14; kidney-expressed chemokine CXC; musculus CXC chemokine MIP-2gamma; B-cell and monocyte-activating chemokine; small inducible cytokine subfamily B (Cys-X-Cys), member 14; KS1; Kec; BMAC; BRAK; NJAC; MIP-2g; Scyb14; AI414372; bolekine; MIP2gamma; 1110031L23Rik; 1200006I23Rik; MGC90667;
Gene ID : 57266
mRNA Refseq : NM_019568
Protein Refseq : NP_062514
UniProt ID : Q9WUQ5

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the relationship of CXCL14 protein to other genes or proteins? 09/14/2022

CXCL14 protein has a complex relationship with other genes or proteins, and can interact with other genes or proteins and participate in a variety of biochemical reactions.

What is the specific role of CXCL14 protein in tumors? 02/18/2022

CXCL14 plays a dual role in tumors, on the one hand, it can inhibit the proliferation and metastasis of tumor cells, and on the other hand, it can promote the immune escape of tumor cells.

What are the types of mutations in CXCL14 protein? 05/03/2021

The types of mutations in CXCL14 protein include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.

Could disease be treated by modulating CXCL14 protein levels? 09/12/2020

There are currently no drugs that directly regulate the levels of CXCL14 protein, but some diseases associated with CXCL14 protein can be treated by regulating its expression or inhibiting its activity.

How are mutations in CXCL14 protein detected and analyzed? 03/12/2020

Mutations in the CXCL14 protein can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.

How to study the regulatory mechanism of CXCL14 protein? 12/23/2019

Studying the regulatory mechanism of CXCL14 protein requires a combination of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.

Customer Reviews (3)

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Reviews
10/30/2022

    CXCL14 has important application value in the field of drug research and development, and has achieved certain research results.

    08/15/2022

      Good solubility, can be dissolved in a variety of buffers.

      03/06/2022

        I'm very satisfied. The quality is good and the price is affordable.

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