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| Cat.No.: | Cxcl14-614M |
| Product Overview: | Recombinant Mouse Cxcl14 produced in E. coli is approximately 9.4 kDa, a single non-glycosylated polypeptide chain containing 77amino acids. |
| Description: | Chemokine (C-X-C motif) ligand 14 (CXCL14), also named BRAK, is a small cytokine belonging to the CXC chemokine family. It is constitutively expressed at the mRNA level in certain normal tissues and it possesses chemoattractive activity for activated macrophages, immature dendritic cells and natural killer cells. According to the relevant literature, CXCL14 is associated with tumor development. Moreover, recent evidence revealed that CXCL14 participates in glucose metabolism, feeding behaviour-associated neuronal circuits, and anti-microbial defense. Although CXCL14 receptors have not yet been identified, the intracellular activity of CXCL14 in breast cancer cells suggests that the CXCL14 receptor(s) and signal transduction pathway(s) may be different from those of conventional CXC-type chemokines. Recombinant murine CXCL14 contains 77 amino acid residues and it shares 97 % and 99 % a.a. sequence identity with human and rat CXCL14. |
| Source: | E. coli |
| Species: | Mouse |
| Form: | Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB, 400 mM NaCl, pH 7.4, 5 % trehalose. |
| Bio-activity: | Fully biologically active when compared to standard. The biologically active determined by a chemotaxis bioassay using human monocytes is in a concentration range of 1.0-10 ng/ml. |
| Molecular Mass: | 9.4 kDa |
| AA Sequence: | SKCKCSRKGP KIRYSDVKKL EMKPKYPHCE EKMVIVTTKS MSRYRGQEHC LHPKLQSTKR FIKWYNAWNE KRRVYEE |
| Endotoxin: | Less than 1 EU/μg of rMuBRAK/CXCL14 as determined by LAL method. |
| Purity: | >95% by SDS-PAGE and HPLC analyses. |
| Usage: | This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE. |
| Storage: | This lyophilized preparation is stable at 2-8 centigrade, but should be kept at -20 centigrade for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 centigrade. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 centigrade to -70 centigrade. Avoid repeated freeze/thaw cycles. |
| Reconstitution: | We recommend that this vial be briefy centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 centigrade. Further dilutions should be made in appropriate buffered solutions. |
| Gene Name: | Cxcl14 chemokine (C-X-C motif) ligand 14 [ Mus musculus ] |
| Official Symbol: | Cxcl14 |
| Synonyms: | CXCL14; chemokine (C-X-C motif) ligand 14; C-X-C motif chemokine 14; chemokine BRAK; small-inducible cytokine B14; kidney-expressed chemokine CXC; musculus CXC chemokine MIP-2gamma; B-cell and monocyte-activating chemokine; small inducible cytokine subfamily B (Cys-X-Cys), member 14; KS1; Kec; BMAC; BRAK; NJAC; MIP-2g; Scyb14; AI414372; bolekine; MIP2gamma; 1110031L23Rik; 1200006I23Rik; MGC90667; |
| Gene ID: | 57266 |
| mRNA Refseq: | NM_019568 |
| Protein Refseq: | NP_062514 |
| Pathway: | Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Senescence and Autophagy, organism-specific biosystem; |
| Function: | chemokine activity; cytokine activity; |
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