"TFF3" Related Products

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Recombinant Human TFF3

Cat.No.: TFF3-652H
Product Overview: Recombinant Human TFF3 produced in E. coli is approximately 6.5 kDa, a single non-glycosylated polypeptide chain containing 59 amino acids, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds.
Description: The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are secreted in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF-3 is expressed by goblet cells and in the uterus, and has also been shown to express in certain cancers, including colorectal, hepatocellular, and in biliary tumors. TFF3 may be useful as a molecular marker for certain types of cancer, but its role, if any, in tumorigenesis is unknown. TFF3 also promotes airway epithelial cell migration and differentiation.
Source: E. coli
Species: Human
Form: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
Bio-activity: Fully biologically active when compared to standard. The ED 50 determined by a chemotaxis bioassay using human MCF-7 cells is less than 10000 ng/ml, corresponding to a specific activity of >1.0 × 10^2 IU/mg.
Molecular Mass: 6.5 kDa
AA Sequence: EEYVGLSANQ CAVPAKDRVD CGYPHVTPKE CNNRGCCFDS RIPGVPWCFK PLQEAECTF
Endotoxin: Less than 1 EU/μg of rHuTFF3 as determined by LAL method.
Purity: >95% by SDS-PAGE and HPLC analyses.
Usage: This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Storage: This lyophilized preparation is stable at 2-8 centigrade, but should be kept at -20 centigrade for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 centigrade. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 centigrade to -70 centigrade. Avoid repeated freeze/thaw cycles.
Reconstitution: We recommend that this vial be briefy centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at< -20 centigrade. further dilutions should be made in appropriate buffered solutions.>
Gene Name: TFF3 trefoil factor 3 (intestinal) [ Homo sapiens ]
Official Symbol: TFF3
Synonyms: TFF3; trefoil factor 3 (intestinal); trefoil factor 3; HITF; ITF; polypeptide P1.B; P1B; TFI;
Gene ID: 7033
mRNA Refseq: NM_003226
Protein Refseq: NP_003217
MIM: 600633
UniProt ID: Q07654
Chromosome Location: 21q22.3
Pathway: HIF-1-alpha transcription factor network, organism-specific biosystem; IL4-mediated signaling events, organism-specific biosystem;
Function: molecular_function;

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