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Active Recombinant Human PRKD2, GST-tagged

Cat.No. : PRKD2-151H
Product Overview : Recombinant full-length human PKD2 (G848E) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
  • Specification
  • Gene Information
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Description : PKD2(G870E) is a glycine to glutamic acid mutation at 870 aa in PKD2 and appears as a somatic mutation in gastric adenocarcinoma samples. PKD2 is a member of the polycystin protein family and is involved in calcium transport and calcium signaling in renal epithelial cells. PKD2 interacts with polycystin 1 and this complex may be partners in a common signaling cascade involved in tubular morphogenesis. PKD2 may function as a chaperone-like molecule, which may prevent ERAD of PKD2. PKD2 form an interaction network with PKD1 as the rate-limiting component.
Source : Sf9 insect cells using baculovirus
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity : The specific activity of PKD2 (G848E) was determined to be 330 nmol /min/mg
Molecular Mass : ~130 kDa
Purity : >90% by densitometry
Applications : Kinase Assay, Western Blot
Storage : Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1 μg/μl
Gene Name : PRKD2 protein kinase D2 [ Homo sapiens ]
Official Symbol : PRKD2
Synonyms : PRKD2; protein kinase D2; serine/threonine-protein kinase D2; DKFZP586E0820; HSPC187; PKD2; nPKC-D2;
Gene ID : 25865
mRNA Refseq : NM_001079880
Protein Refseq : NP_001073349
MIM : 607074
UniProt ID : Q9BZL6
Chromosome Location : 19q13.2
Pathway : T Cell Receptor Signaling Pathway, organism-specific biosystem;
Function : ATP binding; metal ion binding; nucleotide binding; protein binding; protein kinase C activity; protein kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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