"UBE2R2" Related Products


Recombinant Human UBE2R2, His-tagged

Cat.No.: UBE2R2-209H
Product Overview: Recombinant human UBE2R2 (UBC3B) (2-end) was expressed in E. coli cells using an N-terminal His tag.
Description: UBE2R2 (UBC3B) or ubiquitin-conjugating enzyme E2R 2 encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP therby enhancing beta-catenin degradation. CK2-dependent phosphorylation of CDC34 and UBC3B functions by regulating BTRC substrate recognition. UBE2R2 complements a yeast cdc34 temperature-sensitive mutant. Deletion and site-directed mutagenesis demonstrated that CK2 phosphorylated UBE2R2 in the C-terminal domain at serine-233; mutagenesis of the corresponding serine residue at position 231 of human CDC34/UBC3 showed that this was the major CK2-phosphorylation site in this protein.
Source: E. coli
Species: Human
Tag: His
Form: Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
Molecular Mass: ~32 kDa
Purity: >90% by densitometry
Applications: Western Blot
Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.1 μg/μl
Gene Name: UBE2R2 ubiquitin-conjugating enzyme E2R 2 [ Homo sapiens ]
Official Symbol: UBE2R2
Synonyms: UBE2R2; ubiquitin-conjugating enzyme E2R 2; ubiquitin-conjugating enzyme E2 R2; CDC34B; FLJ20419; MGC10481; UBC3B; ubiquitin-protein ligase R2; ubiquitin carrier protein R2; ubiquitin-conjugating enzyme UBC3B; ubiquitin-conjugating enzyme E2-CDC34B; E2-CDC34B;
Gene ID: 54926
mRNA Refseq: NM_017811
Protein Refseq: NP_060281
MIM: 612506
UniProt ID: Q712K3
Chromosome Location: 9p11.2
Pathway: Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem;
Function: ATP binding; acid-amino acid ligase activity; ligase activity; nucleotide binding; ubiquitin-protein ligase activity;

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