"PFKFB1" Related Products


Recombinant Human PFKFB1, GST-tagged

Cat.No.: PFKFB1-214H
Product Overview: Recombinant full-length human PFKFB1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: PFKFB1 is a member of the family of bifunctional 6-phosphofructo-2-kinase: fructose-2, 6-biphosphatase enzymes which forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Regulation of fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.
Source: Sf9 insect cells using baculovirus
Species: Human
Tag: GST
Form: Recombinant protein stored in 50mM Tis-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Molecular Mass: ~80 kDa
Purity: >95% by densitometry
Applications: Western Blot
Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.1 μg/μl
Gene Name: PFKFB1?6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 [Homo sapiens?(human) ]
Official Symbol: PFKFB1
Synonyms: PFKFB1; F6PK; HL2K; PFRX; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1; PFK/FBPase 1; 6PF-2-K/Fru-2,6-P2ase 1; 6PF-2-K/Fru-2,6-P2ASE liver isozyme; fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase; EC; EC
Gene ID: 5207
mRNA Refseq: NM_001271804
Protein Refseq: ?NP_001258733
MIM: 311790
UniProt ID: P16118
Chromosome Location: Xp11.21
Pathway: Fructose and mannose metabolism; Gluconeogenesis; Glucose metabolism
Function: 6-phosphofructo-2-kinase activity; ATP binding; fructose-2,6-bisphosphate 2-phosphatase activity

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