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Recombinant Human UBA3, GST-tagged
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Cat.No. : | UBA3-254H |
Product Overview : | Recombinant full-length human UBA3 (UBE1C) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
Description : | UBA3 (also known as UBE1C) or ubiquitin-like modifier activating enzyme 3 is a member of the E1 ubiquitin-activating enzyme family. UBA3 associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. The mechanism of NEDD8 activation by APPBP1-UBA3 shows a high degree of conservation with ubiquitin activation by UBA1. The NEDD8-activating enzyme, or NAE, composed of NAE1 and UBA3 subunits, is an essential component for the treatment of cancer disease. |
Source : | Sf9 insect cells using baculovirus |
Species : | Human |
Tag : | GST |
Form : | Recombinant protein stored in 50mM Tis-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Molecular Mass : | ~73 kDa |
Purity : | >95% by densitometry |
Applications : | Western Blot |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1 μg/μl |
Gene Name : | UBA3 ubiquitin-like modifier activating enzyme 3 [ Homo sapiens ] |
Official Symbol : | UBA3 |
Synonyms : | UBA3; ubiquitin-like modifier activating enzyme 3; UBE1C, ubiquitin activating enzyme E1C (homologous to yeast UBA3) , ubiquitin activating enzyme E1C (UBA3 homolog, yeast); NEDD8-activating enzyme E1 catalytic subunit; hUba3; ubiquitin activating enzyme E1 homolog (yeast); NEDD8-activating enzyme E1C; Nedd8-activating enzyme hUba3; ubiquitin-activating enzyme 3; ubiquitin-like modifier-activating enzyme 3; UBA3, ubiquitin-activating enzyme E1 homolog; ubiquitin-activating enzyme E1C (UBA3 homolog, yeast); ubiquitin-activating enzyme E1C (homologous to yeast UBA3); UBE1C; hUBA3; MGC22384; DKFZp566J164; |
Gene ID : | 9039 |
mRNA Refseq : | NM_003968 |
Protein Refseq : | NP_003959 |
MIM : | 603172 |
UniProt ID : | Q8TBC4 |
Chromosome Location : | 3p24.3-p13 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; Coregulation of Androgen receptor activity, organism-specific biosystem; Immune System, organism-specific biosystem; |
Function : | ATP binding; NEDD8 activating enzyme activity; acid-amino acid ligase activity; ligase activity; nucleotide binding; protein binding; protein heterodimerization activity; |
◆ Recombinant Protein
Uba3-6766M | Recombinant Mouse Uba3 Protein, Myc/DDK-tagged | +Inquiry |
UBA3-12635Z | Recombinant Zebrafish UBA3 | +Inquiry |
UBA3-1068C | Recombinant Cynomolgus UBA3 Protein, His-tagged | +Inquiry |
UBA3-6386R | Recombinant Rat UBA3 Protein | +Inquiry |
UBA3-5047R | Recombinant Rhesus monkey UBA3 Protein, His-tagged | +Inquiry |
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◆ Lysates
UBA3-604HCL | Recombinant Human UBA3 293 Cell Lysate | +Inquiry |
UBA3-605HCL | Recombinant Human UBA3 293 Cell Lysate | +Inquiry |
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