Active Recombinant Human MMP11 Protein, Tag Free

• Cat.No.: MMP11-160H
• Product Overview: Produced in E. coli. Active Matrix Metalloproteinase-11 (MMP-11, Stromelysin-3) catalytic domain from human cDNA. The enzyme consists of the catalytic domain of human MMP-11 (Phe98-Ser266, NM_005940) with a C-terminal purification tag. MMPs lacking this domain cannot cleave native collagens; however, activity toward other targets such as gelatin, casein, or peptide substrates is unaffected. It may be an important link between obesity and cancer.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Protein Length: 98-266 aa
• Form: Liquid. In 50mM TRIS, 5mM CaCl2, 300mM NaCl, 20μM ZnCl2, 0.5% Brij-35, and 30% glycerol.
• Bio-activity: Due to its unusual substrate preferences [A(A/Q)(N/A)~(L/Y)(T/V/M/R)(R/K), or G(G/A)E~LR5], MMP-11 cleaves MMP peptide substrates extremely slowly (several hours yield very little product). Therefore, the activity of each lot of MMP-11 is verified by digestion of macromolecules.
• Molecular Mass: 19.3 kDa
• Purity: ≥95% SDS-PAGE
• Storage: Long Term Storage: -80 centigrade
• Shipping: Dry Ice

Gene Information

• Gene Name: MMP11 matrix metallopeptidase 11 (stromelysin 3) [ Homo sapiens (human) ]
• Official Symbol: MMP11
• Synonyms: MMP11; matrix metallopeptidase 11 (stromelysin 3); matrix metalloproteinase 11 (stromelysin 3) STMY3; stromelysin-3; MMP-11; stromelysin III; ST3; SL-3; STMY3
• Gene ID: 4320
• mRNA Refseq: NM_005940
• Protein Refseq: NP_005931
• MIM: 185261
• UniProt ID: P24347