Recombinant Mouse Jag2, Fc-tagged

• Cat.No.: Jag2-383M
• Product Overview: Extracellular domain of mouse Jagged-2 (aa 24-1082) is fused at the C-terminus to the Fc portion of human IgG.

Specification

• Description: Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-kappa;B and C-myc to promote the proliferation and to inhibit the apoptosis of MM cells, showed in the relationship between the incidence of myeloma and drug resistance. Jagged-2 is also involved in limb development.
• Source: HEK293 Cells
• Species: Mouse
• Tag: Fc
• Form: Liquid. 0.2μm-filtered solution in PBS.
• Molecular Mass: ~150kDa (SDS-PAGE)
• Purity: ≥90% (SDS-PAGE)
• Stability: Working aliquots are stable for up to 3 months when stored at -20°C.
• Storage: Short Term Storage: +4°C; Long Term Storage: -20°C. After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

Gene Information

• Gene Name: Jag2 jagged 2 [ Mus musculus ]
• Official Symbol: Jag2
• Synonyms: JAG2; jagged 2; protein jagged-2; syndactylism; sm; Serh; D12Ggc2e; mJagged2-1
• Gene ID: 16450
• mRNA Refseq: NM_010588
• Protein Refseq: NP_034718
• Pathway: Delta-Notch Signaling Pathway, organism-specific biosystem; Notch Signaling Pathway, organism-specific biosystem; Notch signaling pathway, organism-specific biosystem; Notch signaling pathway, conserved biosystem; Signal Transduction, organism-specific biosystem; Signaling by NOTCH, organism-specific biosystem; Signaling by NOTCH2, organism-specific biosystem
• Function: Notch binding; growth factor activity