Active Recombinant Rat Cd40lg, FLAG-tagged
Cat.No. : | Cd40lg-405R |
Product Overview : | Rat CD40L (aa 115-260) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG-tag. |
- Specification
- Gene Information
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Description : | MegaCD40L is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to CD40L+enhancer combinations. MegaCD40L has been shown to suppress alum-induced IL-1β release and caspase-1 activation in a dose-, CD40- and time dependent manner, without affecting BMDM (Bone marrow-derived macrophages) viability. It also effectively suppressed the inflammasome function triggered by NLRP3 activators. The secretion of caspase-1 independent inflammatory mediators has been shown to be unaltered or even enhanced. |
Source : | CHO Cells |
Species : | Rat |
Tag : | FLAG |
Form : | Lyophilized. Contains PBS. |
Bio-activity : | Induces B cell activation (as demonstrated by dose-dependent upregulation of CD86). |
Molecular Mass : | ~35-40kDa |
Purity : | ≥95% (SDS-PAGE) |
Stability : | Stable for at least 6 months after receipt when stored at -20°C. |
Storage : | Short Term Storage: +4°C; Long Term Storage: -20°C. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions. |
Concentration : | 0.1mg/ml after reconstitution. |
Gene Name : | Cd40lg CD40 ligand [ Rattus norvegicus ] |
Official Symbol : | Cd40lg |
Synonyms : | CD40LG; CD40 ligand; CD40-L; CD40 ligand CD154; tumor necrosis factor ligand superfamily member 5; tumor necrosis factor (ligand) superfamily, member 5; Cd40l; Tnfsf5; |
Gene ID : | 84349 |
mRNA Refseq : | NM_053353 |
Protein Refseq : | NP_445805 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; |
Function : | CD40 receptor binding; CD40 receptor binding; CD40 receptor binding; cytokine activity; molecular_function; tumor necrosis factor receptor binding; |
Products Types
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◆ Lysates | ||
CD40LG-001CCL | Recombinant Canine CD40LG cell lysate | +Inquiry |
CD40LG-1965HCL | Recombinant Human CD40LG cell lysate | +Inquiry |
CD40LG-1205RCL | Recombinant Rat CD40LG cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, there are clinical trials investigating the modulation of CD40LG in autoimmune diseases, exploring its potential role in regulating immune responses that contribute to autoimmunity.
Yes, research suggests that CD40LG modulation might be a viable strategy in the development of treatments for infectious diseases by enhancing immune responses.
The interaction between CD40LG and CD40 is crucial for the activation of B cells, leading to the production of antibodies and the development of an effective immune response.
CD40LG is involved in modulating inflammatory responses by influencing the activation and function of immune cells, contributing to the regulation of the immune system.
CD40LG is being investigated as an adjuvant in vaccine development, aiming to enhance the immune response and improve the efficacy of vaccines against various diseases.
Customer Reviews (3)
Write a reviewThe reliable performance of the CD40LG protein in ELISA and its compatibility with protein electron microscopy structure analysis make it an excellent choice for a wide range of research studies.
Its reliable and accurate performance ensures dependable results, contributing to the advancement of scientific knowledge in various fields of study.
Their knowledgeable and responsive team assists in troubleshooting and finding solutions to any experimental challenges that may arise.
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