Recombinant Mouse Notch2, Fc-tagged
Cat.No. : | Notch2-436M |
Product Overview : | The extracellular domain of mouse Notch2 (aa 26-494) (12 epidermal growth factor-like (EGF) repeats) is fused at the C-terminus to the Fc portion of human IgG1. |
- Specification
- Gene Information
- Related Products
Description : | Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins. |
Source : | CHO Cells |
Species : | Mouse |
Tag : | Fc |
Form : | Lyophilized. Contains PBS. |
Molecular Mass : | ~87kDa (SDS-PAGE) |
Purity : | ≥95% (SDS-PAGE) |
Stability : | Stable for at least 6 months after receipt when stored at -20°C. |
Storage : | Short Term Storage: +4°C; Long Term Storage: -20°C. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions. |
Concentration : | 1mg/ml after reconstitution. |
Publication : |
The Special Role of JAK/STAT, and Notch Signaling Pathways in Cancer Pathogenesis (2023)
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Gene Name : | Notch2 Notch gene homolog 2 (Drosophila) [ Mus musculus ] |
Official Symbol : | Notch2 |
Synonyms : | NOTCH2; Notch gene homolog 2 (Drosophila); neurogenic locus notch homolog protein 2; Motch B; notch 2; N2; AI853703; |
Gene ID : | 18129 |
mRNA Refseq : | NM_010928 |
Protein Refseq : | NP_035058 |
Pathway : | Delta-Notch Signaling Pathway, organism-specific biosystem; Dorso-ventral axis formation, organism-specific biosystem; Dorso-ventral axis formation, conserved biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Notch Signaling Pathway, organism-specific biosystem; Notch signaling pathway, organism-specific biosystem; |
Function : | NF-kappaB binding; calcium ion binding; protein binding; receptor activity; |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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