Recombinant Human RPS3, GST-tagged

• Cat.No.: RPS3-480H
• Product Overview: Human ribosomal protein S3 (aa 1-243) is fused at the N-terminus to a GST-tag.

Specification

• Description: RPS3 (Ribosomal protein S3) is a component of the 40S ribosomal subunit and is an an essential but previously unkown subunit of NF-kappaB involved in the regulation of key genes in rapid cellular activation responses. RPS3 interacts with nm23-H1. The expression of RPS3 reduces the secretion of MMP-9 and the invasive metastatic potential in HT1080 cells. The phosphorylated ERK is reduced by the expression of RPS3.
• Source: E. coli
• Species: Human
• Tag: GST
• Form: Liquid. 0.2μm-filtered solution in 25mM TRIS-Cl, pH 8.5, containing 1mM DTT.
• Molecular Mass: ~50kDa (SDS-PAGE)
• Purity: ≥90% (SDS-PAGE)
• Stability: Working aliquots are stable for up to 3 months when stored at -20°C.
• Storage: Short Term Storage: +4°C; Long Term Storage: -20°C. After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

Gene Information

• Gene Name: RPS3 ribosomal protein S3 [ Homo sapiens ]
• Official Symbol: RPS3
• Synonyms: RPS3; ribosomal protein S3; 40S ribosomal protein S3; FLJ26283; FLJ27450; IMR 90 ribosomal protein S3; MGC87870; S3; IMR-90 ribosomal protein S3
• Gene ID: 6188
• mRNA Refseq: NM_001005
• Protein Refseq: NP_000996
• MIM: 600454
• UniProt ID: P23396
• Chromosome Location: 11q13.3-q13.5
• Pathway: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem; Cap-dependent Translation Initiation, organism-specific biosystem; Cytoplasmic Ribosomal Proteins, organism-specific biosystem; Disease, organism-specific biosystem; Eukaryotic Translation Elongation, organism-specific biosystem; Eukaryotic Translation Initiation, organism-specific biosystem; Eukaryotic Translation Termination, organism-specific biosystem
• Function: DNA-(apurinic or apyrimidinic site) lyase activity; NF-kappaB binding; damaged DNA binding; endonuclease activity; iron-sulfur cluster binding; mRNA binding; protein binding; protein kinase binding; structural constituent of ribosome; structural constituent of ribosome