Active Recombinant Human TNFRSF10A, Fc-tagged
Cat.No. : | TNFRSF10A-524H |
Product Overview : | The extracellular domain of human TRAIL-R1 (aa 24-239) is fused to the Fc portion of human IgG1. |
- Specification
- Gene Information
- Related Products
Description : | TRAIL-R1 (DR4; CD261) is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB. |
Source : | HEK293 Cells |
Species : | Human |
Tag : | Fc |
Form : | Lyophilized. Contains PBS. |
Bio-activity : | Blocks human or mouse TRAIL activity in a concentration of 1-10μg/ml. |
Molecular Mass : | ~52kDa (SDS-PAGE) |
Purity : | ≥95% (SDS-PAGE) |
Stability : | Stable for at least 6 months after receipt when stored at -20°C. |
Storage : | Short Term Storage: +4°C; Long Term Storage: -20°C. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions. |
Concentration : | 1mg/ml after reconstitution. |
Gene Name : | TNFRSF10A tumor necrosis factor receptor superfamily, member 10a [ Homo sapiens ] |
Official Symbol : | TNFRSF10A |
Synonyms : | TNFRSF10A; tumor necrosis factor receptor superfamily, member 10a; tumor necrosis factor receptor superfamily member 10A; Apo2; CD261; DR4; TRAILR 1; TRAIL-R1; TRAIL receptor 1; death receptor 4; cytotoxic TRAIL receptor; TNF-related apoptosis-inducing ligand receptor 1; tumor necrosis factor receptor superfamily member 10a variant 2; APO2; TRAILR1; TRAILR-1; MGC9365; |
Gene ID : | 8797 |
mRNA Refseq : | NM_003844 |
Protein Refseq : | NP_003835 |
MIM : | 603611 |
UniProt ID : | O00220 |
Chromosome Location : | 8p21 |
Pathway : | Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Direct p53 effectors, organism-specific biosystem; Influenza A, organism-specific biosystem; Influenza A, conserved biosystem; |
Function : | TRAIL binding; death receptor activity; protein binding; receptor activity; transcription factor binding; |
Products Types
◆ Recombinant Protein | ||
TNFRSF10A-3168H | Recombinant Human TNFRSF10A protein(Met1-Asn239), His-tagged | +Inquiry |
TNFRSF10A-461H | Recombinant Human TNFRSF10A Protein, Fc-tagged | +Inquiry |
TNFRSF10A-460H | Recombinant Human TNFRSF10A Protein, His-tagged | +Inquiry |
TNFRSF10A-5249H | Recombinant Human TNFRSF10A Protein (Met1-Asn239), C-His tagged | +Inquiry |
TNFRSF10A-248H | Active Recombinant Human TNFRSF10A, Fc Chimera | +Inquiry |
◆ Lysates | ||
TNFRSF10A-2180HCL | Recombinant Human TNFRSF10A cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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