"TGFB1" Related Products

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Recombinant Human TGFB1

Cat.No.: TGFB1-120H
Product Overview: Recombinant human TGF-b1 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.
Description: This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
Source: CHO cells
Species: Human
Bio-activity: Determined by TGF-β1’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The expected ED50 is ≤0.05 ng/ml, corresponding to a specific activity of ≥2 x 10^7 units/mg.
Molecular Mass: 25.0 kDa
AA Sequence: ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS
Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.
Gene Name: TGFB1 transforming growth factor, beta 1 [ Homo sapiens(human) ]
Official Symbol: TGFB1
Synonyms: TGFB1; CED; LAP; DPD1; TGFB; TGFbeta; transforming growth factor, beta 1; transforming growth factor beta-1; TGF-beta-1; TGF-beta 1 protein; latency-associated peptide
Gene ID: 7040
mRNA Refseq: NM_000660
Protein Refseq: NP_000651
MIM: 190180
UniProt ID: P01137
Chromosome Location: 19q13.1
Pathway: ACE Inhibitor Pathway; Cardiac Progenitor Differentiation; Chagas disease (American trypanosomiasis)
Function: enzyme binding; protein N-terminus binding; protein heterodimerization activity

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