Native Bovine TG

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Native Bovine TG

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Cat.No. : TG-121B
Product Overview : Native Bovine TG was was purified from bovine thyroid.
Description : Bovine thyroglobulin is a large, tetrameric glycoprotein produced in the thyroid gland as a precursor to thyroid hormones. Its large size and absence from plasma under normal conditions makes it very immunogenic and reduces the chance that antibodies to this carrier protein will cross-react with plasma proteins in immunoassays. Haptens may be conjugated to thyroglobulin via accessible secondary amines. Iodine-containing protein that is stored in the thyroid gland. Converted into circulating thyroxines when the thyroid is stimulated by thyroid-stimulating hormone (TSH) from the pituitary. Because its expression is unique to the thyroid, it is a sensitive indicator of recurrence or metastasis of thyroid cancer that has been treated by thyroid ablation.
Source : bovine thyroid
Species : Bovine
Molecular Mass : ~670 kDa
Purity : ≥90% (agarose gel electrophoresis)
Applications : Bovine thyroglobulin was shown to stimulate proliferation in rat thyroid follicular cells as well as in primary porcine thyroid epithelial cells. This effect was mediated through PI3K signaling. Often used as a carrier protein for the production of antibodies. Its advantage is the large number of tyrosine residues that can be used for conjugation using the diazo reaction.
Storage : Store at -20°C.
Reconstitution : H2O: soluble 20 mg/mL
Gene Name : TG thyroglobulin [ Bos taurus ]
Official Symbol : TG
Synonyms : thyroglobulin; hereditary goitre
Gene ID : 280706
mRNA Refseq : NM_173883
Protein Refseq : NP_776308
UniProt ID : P01267
Chromosome Location : 14q12-q15
Pathway : Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Thyroid hormone synthesis, organism-specific biosystem
Function : hormone activity; NOT neurexin family protein binding; NOT receptor activity

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