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Recombinant Human CD200, Fc-tagged

Cat.No. : CD200-165H
Product Overview : Recombinant Human CD200 /OX-2 Protein, With C-Fc Tag (rhCD200 Fc Chimera) Gln 31 - Gly 232 was produced in human 293 cells (HEK293).
Description : CD200 also known as OX-2 membrane glycoprotein (OX-2), is a type-1 membrane glycoprotein, which contains two immunoglobulin domains (1 Ig-like C2-type (immunoglobulin-like) domain and Ig-like V-type (immunoglobulin-like) domain), and thus belongs to the immunoglobulin superfamily. CD200 / OX-2 is widely expressed in multiple cell types. CD200 interacts with a structurally related receptor (CD200R) expressed mainly on myeloid cells and is involved in regulation of macrophage and mast cell function. OX-2 / CD200 and CD200R associate via their respective N-terminal Ig-like domains. CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.
Source : HEK293
Species : Human
Tag : Fc
Form : Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.0. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Bio-activity : Measured by its binding ability in a functional ELISA. Immobilized recombinant human CD200R1 at 2 μg/ml,the concentration of rhCD200 Fc Chimera that produces 50% of the optimal binding response is appoximately 2.0?16 ng/ml.
Molecular Mass : rhCD200 Fc Chimera, fused with Fc fragment of human IgG1 at the C-terminus, has a calculated MW of 48.6 kDa. The predicted N-terminus is Gln 31. DTT-reduced Protein migrates as 50-68 kDa due to glycosylation.
Endotoxin : Less than 1.0 EU per μg of the rhCD200 Fc Chimera by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4oC-8oC); After reconstitution under sterile conditions for 1 month (4oC-8oC) or 3 months (-20oC to -70oC).
Gene Name : CD200 CD200 molecule [ Homo sapiens (human) ]
Official Symbol : CD200
Synonyms : CD200; MRC; MOX1; MOX2; OX-2; CD200 molecule; OX-2 membrane glycoprotein; CD200 antigen; MRC OX-2 antigen; antigen identified by monoclonal antibody MRC OX-2
Gene ID : 4345
mRNA Refseq : NM_005944
Protein Refseq : NP_005935
MIM : 155970
UniProt ID : P41217
Chromosome Location : 3q13.2
Pathway : Adaptive Immune System; Immune System; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Function : protein binding

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