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Recombinant Human CD200, Fc-tagged

Cat.No.: CD200-165H
Product Overview: Recombinant Human CD200 /OX-2 Protein, With C-Fc Tag (rhCD200 Fc Chimera) Gln 31 - Gly 232 was produced in human 293 cells (HEK293).
Description: CD200 also known as OX-2 membrane glycoprotein (OX-2), is a type-1 membrane glycoprotein, which contains two immunoglobulin domains (1 Ig-like C2-type (immunoglobulin-like) domain and Ig-like V-type (immunoglobulin-like) domain), and thus belongs to the immunoglobulin superfamily. CD200 / OX-2 is widely expressed in multiple cell types. CD200 interacts with a structurally related receptor (CD200R) expressed mainly on myeloid cells and is involved in regulation of macrophage and mast cell function. OX-2 / CD200 and CD200R associate via their respective N-terminal Ig-like domains. CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.
Source: HEK293
Species: Human
Tag: Fc
Form: Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.0. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Bio-activity: Measured by its binding ability in a functional ELISA. Immobilized recombinant human CD200R1 at 2 μg/ml,the concentration of rhCD200 Fc Chimera that produces 50% of the optimal binding response is appoximately 2.0?16 ng/ml.
Molecular Mass: rhCD200 Fc Chimera, fused with Fc fragment of human IgG1 at the C-terminus, has a calculated MW of 48.6 kDa. The predicted N-terminus is Gln 31. DTT-reduced Protein migrates as 50-68 kDa due to glycosylation.
Endotoxin: Less than 1.0 EU per μg of the rhCD200 Fc Chimera by the LAL method.
Purity: >95% as determined by SDS-PAGE.
Storage: Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4oC-8oC); After reconstitution under sterile conditions for 1 month (4oC-8oC) or 3 months (-20oC to -70oC).
Gene Name: CD200 CD200 molecule [ Homo sapiens (human) ]
Official Symbol: CD200
Synonyms: CD200; MRC; MOX1; MOX2; OX-2; CD200 molecule; OX-2 membrane glycoprotein; CD200 antigen; MRC OX-2 antigen; antigen identified by monoclonal antibody MRC OX-2
Gene ID: 4345
mRNA Refseq: NM_005944
Protein Refseq: NP_005935
MIM: 155970
UniProt ID: P41217
Chromosome Location: 3q13.2
Pathway: Adaptive Immune System; Immune System; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Function: protein binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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