Recombinant Human CD200 protein, Fc-tagged
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|Product Overview :||Recombinant Human CD200 protein (Gln31-Gly232) was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293).|
|Description :||CD200 is also known as OX-2 membrane glycoprotein (OX-2), is a type-1 membrane glycoprotein, which contains two immunoglobulin domains (1 Ig-like C2-type (immunoglobulin-like) domain and Ig-like V-type (immunoglobulin-like) domain), and thus belongs to the immunoglobulin superfamily. CD200/OX-2 is widely expressed in multiple cell types. CD200 interacts with a structurally related receptor (CD200R) expressed mainly on myeloid cells and is involved in regulation of macrophage and mast cell function. OX-2/CD200 and CD200R associate via their respective N-terminal Ig-like domains. CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.|
|Tag :||human IgG1 Fc|
|Predicted N Terminal :||Gln 31|
|Form :||Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5, 10% trehalose.|
|Molecular Mass :||The protein has a calculated MW of 48.6 kDa. The protein migrates as 50-68 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.|
|Protein length :||Gln31-Gly232|
|Endotoxin :||Less than 1.0 EU per μg by the LAL method.|
|Purity :||>95% as determined by SDS-PAGE.|
|Storage :||For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
|Reconstitution :||It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.|
|SDS-PAGE of CD200-165H :||
Human CD200, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
|Bioactivity-ELISA of CD200-165H :||
Immobilized Human CD200, Fc Tag at 2 μg/mL (100 μL/well) can bind Biotinylated Human CD200 R1, Fc,Avitag with a linear range of 0.5-7.8 ng/mL.
|Gene Name :||CD200|
|Official Symbol :||CD200|
|Synonyms :||MRC; MOX1; MOX2; OX-2|
|Gene ID :||4345|
|mRNA Refseq :||NM_005944.7|
|Protein Refseq :||NP_005935.4|
|UniProt ID :||P41217|
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