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Recombinant Human PLIN2, T7 tagged

Cat.No. : PLIN2-201H
Product Overview : PLIN2, 1-437aa, Human, T7 tag, E.coli
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  • Gene Information
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Description : PLIN2 belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Recombinant human PLIN2, fused to T7-tag at N-terminus, was expressed in E.coli.
Source : E.coli
Species : Human
Tag : T7 tag
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M UREA, 10% glycerol
Molecular Mass : 49.3kDa (450aa)
Protein length : 1-437aa
AA Sequence : MASMTGGQQM GRGSMASVAV DPQPSVVTRV VNLPLVSSTY DLMSSAYLST KDQYPYLKSV CEMAENGVKT ITSVAMTSAL PIIQKLEPQI AVANTYACKG LDRIEERLPI LNQPSTQIVA NAKGAVTGAK DAVTTTVTGA KDSVASTITG VMDKTKGAVT GSVEKTKSVV SGSINTVLGS RMMQLVSSGV ENALTKSELL VEQYLPLTEE ELEKEAKKVE GFDLVQKPSY YVRLGSLSTK LHSRAYQQAL SRVKEAKQKS QQTISQLHST VHLIEFARKN VYSANQKIQD AQDKLYLSWV EWKRSIGYDD TDESHCAEHI ESRTLAIARN LTQQLQTTCH TLLSNIQGVP QNIQDQAKHM GVMAGDIYSV FRNAASFKEV SDSLLTSSKG QLQKMKESLD DVMDYLVDNT PLNWLVGPFY PQLTESQNAQ DQGAEMDKSS QETQRSEHKT H
Purity : >85% by SDS - PAGE
Storage : Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration : 1 mg/ml (determined by Bradford assay)
Gene Name : PLIN2 perilipin 2 [ Homo sapiens ]
Official Symbol : PLIN2
Synonyms : PLIN2; perilipin 2; ADFP, adipose differentiation related protein; perilipin-2; adipophilin; ADRP; adipose differentiation-related protein; ADFP; MGC10598;
Gene ID : 123
mRNA Refseq : NM_001122
Protein Refseq : NP_001113
MIM : 103195
UniProt ID : Q99541
Chromosome Location : 9p22.1
Pathway : Adipogenesis, organism-specific biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; HIF-1-alpha transcription factor network, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; PPARA Activates Gene Expression, organism-specific biosystem; Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How are the interactions between PLIN2 and other proteins regulated? 12/07/2022

The interaction between PLIN2 and other proteins is regulated by the formation of complexes or the regulation of signal transduction pathways. These interactions can be influenced by a variety of factors, such as nutrients, hormones, and inflammatory factors.

What is the relationship between PLIN2 and cardiovascular disease? 12/03/2021

Some studies have suggested that the expression level of PLIN2 may be associated with the occurrence and progression of cardiovascular disease. High levels of PLIN2 may be associated with an increased risk of cardiovascular diseases such as atherosclerosis, myocardial hypertrophy, and heart failure.

Can the function of PLIN2 be studied by gene knockout or knockdown techniques? 08/15/2021

The function of PLIN2 can be studied through gene knockout or knockdown techniques, such as using techniques such as CRISPR-Cas9 or RNAi. These techniques can create cellular models of PLIN2 deletion or reduction to observe its effects on fat storage and breakdown, among other things.

What is the role of PLIN2 in obesity and diabetes? 04/11/2021

PLIN2 plays an important role in obesity and diabetes. It may influence the development of obesity and diabetes by regulating adipocyte differentiation, insulin sensitivity, and lipid metabolism.

How can the function of PLIN2 be studied by overexpression techniques? 01/02/2021

PLIN2 can be studied through overexpression techniques, such as the use of gene transduction or viral transduction. These techniques can increase the expression level of PLIN2 to observe its effects on fat storage and breakdown, among other things.

How does the expression level of PLIN2 relate to the occurrence and progression of the disease? 08/30/2020

Some studies have shown that PLIN2 expression levels may be associated with obesity, diabetes, and cardiovascular disease, among others. High levels of PLIN2 may be associated with increased susceptibility to disease, while low levels of PLIN2 may be associated with decreased susceptibility to disease.

Customer Reviews (3)

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Reviews
01/15/2022

    Operation is simple and does not require complex operation steps.

    10/06/2021

      Quality I use is very good and I have recommended this product to my colleagues and friends.

      01/24/2021

        Sensitivity in Western blot is very high and low concentrations of the target protein can be detected.

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