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Recombinant Human SFTPD, His-tagged

Cat.No. : SFTPD-238H
Product Overview : SFTPD, 224-375aa, Human, His tag, E.coli
  • Specification
  • Gene Information
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Description : SFTPD, as known as Surfactant pulmonary-associated protein D, is a member of the collectin family of C-type lectins that is synthesized in many tissues including respiratory epithelial cells in the lung, and contains one C-type lectin domain and one collagen-like domain. It is humoral molecules of the innate immune system, and is considered a functional candidate in chronic periodontitis. Besides it is involved in the development of acute and chronic inflammation of the lung. Several human lung diseases are characterized by decreased levels of bronchoalveolar SFTPD. Recombinant human SFTPD protein, fused to His-tag at N-terminus, was expressed in E.coli
Source : E.coli
Species : Human
Tag : His-tag
Form : Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.4M Urea
Molecular Mass : 18.9 kDa (175aa)
Protein length : 224-375aa
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSVASLRQQ VEALQGQVQH LQAAFSQYKK VELFPNGQSV GEKIFKTAGF VKPFTEAQLL CTQAGGQLAS PRSAAENAAL QQLVVAKNEA AFLSMTDSKT EGKFTYPTGE SLVYSNWAPG EPNDDGGSED CVEIFTNGKW NDRACGEKRL VVCEF
Purity : >80% by SDS - PAGE
Storage : Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration : 1mg/ml (determined by Bradford assay)
Gene Name : SFTPD surfactant protein D [ Homo sapiens ]
Official Symbol : SFTPD
Synonyms : SFTPD; surfactant protein D; SFTP4, surfactant, pulmonary associated protein D; pulmonary surfactant-associated protein D; COLEC7; SP D; collectin 7; collectin-7; lung surfactant protein D; pulmonary surfactant apoprotein; surfactant, pulmonary-associated protein D; surfactant-associated protein, pulmonary 4; SP-D; PSP-D; SFTP4;
Gene ID : 6441
mRNA Refseq : NM_003019
Protein Refseq : NP_003010
MIM : 178635
UniProt ID : P35247
Chromosome Location : 10q22.2-q23.1
Pathway : FOXA1 transcription factor network, organism-specific biosystem; Phagosome, organism-specific biosystem; Phagosome, conserved biosystem; Regulation of retinoblastoma protein, organism-specific biosystem;
Function : bacterial cell surface binding; protein binding; sugar binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How is SFTPD involved in the regulation of inflammation? 02/14/2022

SFTPD regulates immune cell activity, helping to control inflammation in the lungs.

Are there known genetic variations in SFTPD associated with specific diseases? 09/04/2021

Certain genetic variations in SFTPD have been linked to increased susceptibility to respiratory diseases.

What is the primary function of SFTPD in the immune system? 08/15/2020

SFTPD enhances the clearance of pathogens and modulates immune responses.

What role does SFTPD play in respiratory infections? 06/15/2020

It binds to pathogens, aiding in their clearance and protecting against respiratory infections.

What therapeutic strategies are being explored that involve SFTPD? 03/30/2020

Therapies are being explored to modulate SFTPD levels in diseases like COPD and pulmonary fibrosis.

How does SFTPD contribute to pulmonary homeostasis? 01/01/2019

It maintains lung function by participating in surfactant homeostasis and immune regulation.

In which tissues is SFTPD predominantly expressed? 10/13/2018

SFTPD is primarily expressed in the lungs, especially in alveolar and bronchiolar epithelial cells.

Customer Reviews (3)

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Reviews
11/17/2022

    Quality product, fast delivery.

    04/21/2021

      Fast, efficient, and reliable.

      02/06/2018

        Excellent performance in assay.

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