"F2" Related Products

Native Cattle Thrombin

Cat.No.: Thrombin-21H
Description: Thrombin enzyme (Activated Factor IIa) is an important clotting promoter that controls the transformation of soluble fibrinogen to insoluble active fibrin strands. Thrombin is a coagulation protein and a serine protease (EC 3.4.21.5) that catalyzes many coagulation-related reactions. Thrombin triggers factor-XI, factor-V, Factor-XIII and factor-VIII. Thrombin endorses platelet activation, using activation of protease-activated receptors on the platelet. As a result of its high proteolytic specificity, thrombin has become an important biochemical protein. The thrombin cleavage site (Leu-Val-Pro-Arg-Gly-Ser) is widely used in linker regions of recombinant fusion protein constructs. After the purification of the fusion protein, thrombin is used to cleave between the Arginine and Glycine residues of the cleavage site, efficiently removing the purification tag from the protein of interest with a high degree of specificity.
Source: Cattle Blood
Species: Cattle
Form: Sterile Filtered White lyophilized (freeze-dried) powder.
Bio-activity: 150 u/mg
Purity: Single band
Storage: Upon reconstitution Thrombin should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Reconstitution: It is recommended to reconstitute the lyophilized Thrombin in sterile 18 M Ω-cm H2O.
Gene Name: F2 coagulation factor II (thrombin) [ Bos taurus ]
Official Symbol: F2
Synonyms: prothrombin; thrombin
Gene ID: 280685
mRNA Refseq: NM_173877
Protein Refseq: NP_776302
UniProt ID: P00735
Chromosome Location: chromosome: 15
Pathway: Cell surface interactions at the vascular wall, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Common Pathway, organism-specific biosystem
Function: calcium ion binding; fibrinogen binding; protein binding

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