Recombinant Human CTLA4, His-tagged, Biotinylated CTLA4-255H

Recombinant Human CTLA4, His-tagged, Biotinylated

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Cat.No. : CTLA4-255H Optional Service: Optional requirements on this protein
Product Overview : Human CTLA4 /CD152 Protein, Biotinylated (Biotinylated CTLA4 /CD152) Ala 37 - Phe 162, was labeled with biotin based on rhCTLA4 Protein, which was produced in human 293 cells (HEK293).
Description : This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Source : HEK293
Species : Human
Tag : His
Form : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose are added as protectants before lyophilization.
Molecular Mass : Biotinylated CTLA4 /CD152, fused with 6×His tag at the C-terminus, has a calculated MW of 14.3 kDa. The predicted N-terminus is Ala 37 . DTT-reduced Protein migrates as 25 kDa due to glycosylation.
Endotoxin : Less than 1.0 EU per μg of the Biotinylated CTLA4 /CD152 by the LAL method.
Purity : >95% as determined by reduced SDS-PAGE.
Storage : Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C).
Gene Name : CTLA4 cytotoxic T-lymphocyte-associated protein 4 [ Homo sapiens ]
Official Symbol : CTLA4?
Synonyms : CTLA4; cytotoxic T-lymphocyte-associated protein 4; celiac disease 3 , CELIAC3; cytotoxic T-lymphocyte protein 4; CD; CD28; CD152; GSE; ICOS; CD152 isoform; celiac disease 3; cytotoxic T-lymphocyte antigen 4; cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated serine esterase-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; GRD4; CTLA-4; IDDM12; CELIAC3;
Gene ID : 1493
mRNA Refseq : NM_001037631
Protein Refseq : NP_001032720
UniProt ID : P16410
Chromosome Location : 2q33
Pathway : Adaptive Immune System, organism-specific biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; CTLA4 inhibitory signaling, organism-specific biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem;
Function : protein binding;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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