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Recombinant Human myostatin Propepetide

Cat. No. : MSTN-120H
Product Overview : Recombinant Human of the human Myostatin Propeptide produced inE.colia molecular mass of 27.8 kDa and containing 244 amino acid residues.
Description : Myostatin (GDF-8), a member of the TGFbeta superfamily, is a potent and specific negative regulator of skeletal muscle mass. In serum, myostatin circulates as part of a latent complex containing myostatin propeptide and/or follistatin-related gene. The myostatin propeptide is known to bind and inhibit myostatin in vitro. This interaction is relevant in vivo, with a majority (>70%) of myostatin in serum bound to its propeptide. The myostatin propeptide is negative regulator of myostatin in vivo.
Source : Escherichia Coli.
Amino acid sequence : MNENSEQKE NVEKEGLCNA CTWRQNTKSS RIEAIKIQIL SKLRLETAPN ISKDVIRQLL PKAPPLRELI DQYDVQRDDS SDGSLEDDDY HATTETIITM PTESDFLMQV DGKPKCCFFK FSSKIQYNKV VKAQLWIYLR PVETPTTVFV QILRLIKPMK DGTRYTGIRS LKLDMNPGTG IWQSIDVKTV LQNWLKQPES NLGIEIKALD ENGHDLAVTF PGPGEDGLNP FLEVKVTDTP KRSRR.
Physical Appearance : Sterile Filtered white lyophilized (freeze-dried) powder.
Purity : Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation : Lyophilized from 10 mM Acetic Acid.
Applications : Western blotting, ELISA.
Solubility : It is recommended to reconstitute the lyophilized Myostatin Propeptide in sterile 20 mM HCl at 0.1 mg/ml, which can then be further diluted to other aqueous solutions.
Stability : Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time. The lyophilized protein remains stable until the expiry date when stored at -20°C.
Gene Name : MSTN myostatin [ Homo sapiens ]
Synonyms : MSTN; myostatin; GDF8; growth differentiation factor 8; GDF-8; Myostatin
Gene ID : 2660
mRNA Refseq : NM_005259
Protein Refseq : NP_005250
MIM : 601788
UniProt ID : O14793
Chromosome Location : 2q32.2
Function : cytokine activity; growth factor activity

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