Recombinant Human myostatin Propepetide

• Cat.No.: MSTN-120H
• Product Overview: Recombinant Human of the human Myostatin Propeptide produced inE.colia molecular mass of 27.8 kDa and containing 244 amino acid residues.

Specification

• Cat. No.: MSTN-120H
• Description: Myostatin (GDF-8), a member of the TGFbeta superfamily, is a potent and specific negative regulator of skeletal muscle mass. In serum, myostatin circulates as part of a latent complex containing myostatin propeptide and/or follistatin-related gene. The myostatin propeptide is known to bind and inhibit myostatin in vitro. This interaction is relevant in vivo, with a majority (>70%) of myostatin in serum bound to its propeptide. The myostatin propeptide is negative regulator of myostatin in vivo.
• Source: Escherichia Coli.
• Amino acid sequence: MNENSEQKE NVEKEGLCNA CTWRQNTKSS RIEAIKIQIL SKLRLETAPN ISKDVIRQLL PKAPPLRELI DQYDVQRDDS SDGSLEDDDY HATTETIITM PTESDFLMQV DGKPKCCFFK FSSKIQYNKV VKAQLWIYLR PVETPTTVFV QILRLIKPMK DGTRYTGIRS LKLDMNPGTG IWQSIDVKTV LQNWLKQPES NLGIEIKALD ENGHDLAVTF PGPGEDGLNP FLEVKVTDTP KRSRR.
• Physical Appearance: Sterile Filtered white lyophilized (freeze-dried) powder.
• Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Formulation: Lyophilized from 10 mM Acetic Acid.
• Applications: Western blotting, ELISA.
• Solubility: It is recommended to reconstitute the lyophilized Myostatin Propeptide in sterile 20 mM HCl at 0.1 mg/ml, which can then be further diluted to other aqueous solutions.
• Stability: Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time. The lyophilized protein remains stable until the expiry date when stored at -20°C.

Gene Information

• Gene Name: MSTN myostatin [ Homo sapiens ]
• Synonyms: MSTN; myostatin; GDF8; growth differentiation factor 8; GDF-8; Myostatin
• Gene ID: 2660
• mRNA Refseq: NM_005259
• Protein Refseq: NP_005250
• MIM: 601788
• UniProt ID: O14793
• Chromosome Location: 2q32.2
• Function: cytokine activity; growth factor activity

Reviews

04/04/2021

The MSTN protein surpasses expectations in terms of quality and will undoubtedly fulfill my experimental requirements.

11/15/2020

the manufacturer of MSTN provides exceptional technical support, offering valuable assistance in troubleshooting and experimental design.

02/01/2020

The outstanding level of customer service adds extra reassurance and confidence in using the MSTN protein for my scientific investigations.

Q&As

How do MSTN inhibitors work in the context of muscle-related disorders?

MSTN inhibitors work by blocking the activity of the MSTN protein, thus promoting muscle growth and potentially reversing muscle loss.

Are there any known side effects of using MSTN inhibitors in clinical trials?

Some potential side effects include joint stiffness, increased risk of fractures, and insulin resistance, which require close monitoring during trials.

How does the overexpression of MSTN affect muscle development?

Overexpression of MSTN can lead to muscle atrophy and decreased muscle mass.

How do researchers regulate the dosage of MSTN protein therapy to ensure safety and efficacy?

Researchers carefully monitor the dosage and administration of MSTN protein therapy through preclinical and clinical studies to establish the optimal therapeutic dose.

What are the potential risks associated with MSTN protein therapy?

Possible risks include unintended effects on other organ systems and potential complications related to excessive muscle growth.