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Recombinant Human MSLN protein, His-tagged, Biotin Labeled.

Cat.No. : MSLN-10623H
Product Overview : Recombinant Human MSLN(Glu 296 - Gly 580) fused with His tag at C-terminal was expressed in HEK293.
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Description : Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.
Source : HEK293
Species : Human
Tag : His
Predicted N Terminal : Glu 296
Form : Lyophilized from 0.22µm filtered solution in PBS (pH 7.4) with Trehalose as protectant.
Molecular Mass : The protein has a calculated MW of 33 kDa. The protein migrates as 38-42 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation.
Protein length : Glu 296 - Gly 580
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Notes : The primary amines in the side chains of lysine residues and the N-terminus of the protein are conjugated with biotins using standard chemical labeling method. A standard biotin reagent (13.5 angstroms) is used in this product.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles.
No activity loss is observed after storage at:
4-8 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : Reconstitute at 100 μg/mL in sterile deionized water. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the COA.
Gene Name : MSLN mesothelin [ Homo sapiens ]
Official Symbol : MSLN
Synonyms : MSLN; mesothelin; CAK1; MPF; CAK1 antigen; megakaryocyte potentiating factor; soluble MPF mesothelin related protein; pre-pro-megakaryocyte-potentiating factor; SMRP;
Gene ID : 10232
mRNA Refseq : NM_001177355
Protein Refseq : NP_001170826
MIM : 601051
UniProt ID : Q13421
Chromosome Location : 16p13.3

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the primary role of MSLN in normal tissues? 12/07/2022

MSLN is normally expressed in mesothelial cells, playing a role in cell adhesion.

How is MSLN expression altered in cancerous cells? 03/19/2022

In cancer, MSLN expression is significantly upregulated.

In which types of cancer is MSLN overexpressed? 03/28/2021

MSLN is overexpressed in mesothelioma, ovarian, and pancreatic cancers.

Are there any therapeutic strategies targeting MSLN in cancer treatment? 02/25/2020

Therapies targeting MSLN include antibody-drug conjugates and CAR-T cell therapies.

How can MSLN levels be detected and measured in clinical settings? 10/07/2019

MSLN levels can be assessed through immunohistochemistry and serum biomarker tests.

What is the prognostic significance of MSLN overexpression in cancer patients? 11/23/2018

MSLN overexpression is often associated with poor prognosis in cancer patients.

How does MSLN contribute to cancer progression and metastasis? 11/07/2018

MSLN promotes tumor cell proliferation, invasion, and resistance to apoptosis.

Customer Reviews (3)

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Reviews
05/22/2022

    Very satisfied, great product.

    03/06/2022

      Product is high-quality.

      09/30/2021

        Excellent for experiments, reliable.

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