Active Recombinant Human MSLN Protein (Glu 296 - Gly 580), Fc-tagged, FITC-Labeled
Cat.No. : | MSLN-316H |
Product Overview : | Recombinant Human MSLN Protein, Fc-tagged, FITC-Labeled is expressed from human HEK293 cells. It contains AA Glu 296 - Gly 580 (Accession # AAH09272.1). It is the FITC labeled form of Human Mesothelin (296-580), Fc Tag. Predicted N-terminus: Glu 296. This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 58.6 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. Conjugate (FITC): Excitation source: 488 nm spectral line, argon-ion laser; Excitation Wavelength: 488 nm; Emission Wavelength: 535 nm. The FITC to protein molar ratio is 1-2.5. The primary amines in the side chains of lysine residues and the N-terminus of the protein are conjugated with FITC using standard chemical labeling method. The residual FITC is removed by molecular seive treatment during purification process. |
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Source : | HEK293 |
Species : | Human |
Tag : | Fc |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant. |
Bio-activity : | Immobilized Human Mesothelin (296-580), Fc Tag, premium grade (Cat. No. MSN-H5253) at 0.5 μg/mL (100 μL/well) can bind Anti-Human MSLN Mab with a linear range of 0.1-3 ng/mL. |
Molecular Mass : | The protein has a calculated MW of 58.6 kDa. The protein migrates as 66-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein Length : | Glu 296 - Gly 580 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. >90% as determined by SEC-MALS. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 centigrade to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | MSLN mesothelin [ Homo sapiens ] |
Official Symbol : | MSLN |
Synonyms : | MSLN; mesothelin; CAK1; MPF; CAK1 antigen; megakaryocyte potentiating factor; soluble MPF mesothelin related protein; pre-pro-megakaryocyte-potentiating factor; SMRP; |
Gene ID : | 10232 |
mRNA Refseq : | NM_001177355 |
Protein Refseq : | NP_001170826 |
MIM : | 601051 |
UniProt ID : | Q13421 |
Products Types
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Msln-4192M | Recombinant Mouse Msln Protein, Myc/DDK-tagged | +Inquiry |
MSLN-380H | Recombinant Human MSLN Protein, Fc-tagged, Biotinylated | +Inquiry |
MSLN-303H | Active Recombinant Human MSLN Protein, His-Avi-tagged, Biotinylated | +Inquiry |
◆ Lysates | ||
MSLN-1343HCL | Recombinant Human MSLN cell lysate | +Inquiry |
MSLN-1316HCL | Recombinant Human MSLN cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionMSLN is normally expressed in mesothelial cells, playing a role in cell adhesion.
In cancer, MSLN expression is significantly upregulated.
MSLN is overexpressed in mesothelioma, ovarian, and pancreatic cancers.
Therapies targeting MSLN include antibody-drug conjugates and CAR-T cell therapies.
MSLN levels can be assessed through immunohistochemistry and serum biomarker tests.
MSLN overexpression is often associated with poor prognosis in cancer patients.
MSLN promotes tumor cell proliferation, invasion, and resistance to apoptosis.
Customer Reviews (3)
Write a reviewVery satisfied, great product.
Product is high-quality.
Excellent for experiments, reliable.
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