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Recombinant Human TARDBP, His-tagged

Cat.No.: TARDBP-85H
Product Overview: Recombinant human TARDBP protein protein, fused to His-tag at N-terminus, was expressed in E.coli.
Description: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.
Source: E.coli
Species: Human
Tag: His
Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.4M urea
Molecular Mass: 48.8 kDa(450aa)
AA Sequence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMSEY IRVTEDENDE PIEIPSEDDG TVLLSTVTAQ FPGACGLRYR NPVSQCMRGV RLVEGILHAP DAGWGNLVYV VNYPKDNKRK MDETDASSAV KVKRAVQKTS DLIVLGLPWK TTEQDLKEYF STFGEVLMVQ VKKDLKTGHS KGFGFVRFTE YETQVKVMSQ RHMIDGRWCD CKLPNSKQSQ DEPLRSRKVF VGRCTEDMTE DELREFFSQY GDVMDVFIPK PFRAFAFVTF ADDQIAQSLC GEDLIIKGIS VHISNAEPKH NSNRQLERSG RFGGNPGGFG NQGGFGNSRG GGAGLGNNQG SNMGGGMNFG AFSINPAMMA AAQAALQSSW GMMGMLASQQ NQSGPSGNNQ NQGNMQREPN QAFGSGNNSY SGSNSGAAIG WGSASNAGSG SGFNGGFGSS MDSKSSGWGM
Purity: > 90% by SDS - PAGE
Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration: 1 mg/ml (determined by Bradford assay)
Gene Name: TARDBP TAR DNA binding protein [ Homo sapiens (human) ]
Official Symbol: TARDBP
Synonyms: TARDBP; ALS10; TDP-43; TAR DNA binding protein; TAR DNA-binding protein 43; TAR DNA-binding protein-43
Gene ID: 23435
mRNA Refseq: NM_007375
Protein Refseq: NP_031401
MIM: 605078
UniProt ID: Q13148
Chromosome Location: 1p36.22
Function: RNA binding; double-stranded DNA binding; identical protein binding

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