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Recombinant human IL7, Active, His-tagged

Cat.No. : IL7-1559H
Product Overview : Recombinant human Interleukin 7 is a glycosylated polypeptide chain containing 160 amino acids (26 -177 of P13232 IL7_HUMAN ), fused to His tag at N-terminal. rHuman IL-7 migrate at approximately 18-25 kDa by SDS-PAGE.
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Description : Interleukin-7 (IL-7) is a member of the interleukin family which regulates the development and survival of lymphoid and myeloid cells. It has a potent effect for the stimulation of the adaptative immune response, it promotes proliferation of lymphoid progenitors (Pre-B, Pro-B and early T cells), and the effects include mobilization, maturation, and maintenance of IL-7 responsive immune cells.The biological functions of IL-7 as a key ""lymphotrophin" in JAK-STAT pathways, PI3 kinase pathway, and Src kinase pathway. IL-7 has also been shown to play a vital role in energy metabolism of T cells and regulating glucose uptake in T lymphocytes through Glut1 via activation of STAT5 and Akt. It has a thymic antiapoptotic effect, and induce the expression of antiapoptotic proteins Bcl-2 and Mcl-1 and the inhibition of preapoptotic proteins Bax and Bad.IL-7 has potential therapeutic applications for the lymphoid reconstitution of immuno-depressed patients (chemotherapy, radiation, AIDS, and bone marrow transplant).
Source : Human recombinant protein expressed in Nicotiana benthamiana. It is produced by transient expression in non-transgenic plants. This product contains no animal–derived components or impurities. Animal Free product.
Species : Human
Tag : His
Form : Recombinan human IL-7 is lyophilized from 10 mM PBS buffer pH 7.5 and 0.2 M NaCl.
Molecular Mass : Approximately 18-25 kDa by SDS-PAGE.
AA Sequence : HHHHHHHHDCDIEGKDGKQYESVLM VSIDQLLDSMKEIGSNCLNNEFNFF KRHICDANKEGMFLFRAARKLRQFL KMNSTGDFDLHLLKVSEGTTILLNC TGQVKGRKPAALGEAQPTKSLEENK SLKEQKKLNDLCFLKRLLQEIKTCW NKILMGTKEH
Endotoxin : < 0.04 eu/μg protein (lal>
Purity : >97% by SDS-PAGE gel
Storage : This lyophilized preparation is stable at 2-8o C for short term, long storage it should be kept at -20oC. Reconstituted protein should be stored in working aliquots at –20°C. Repeated freezing and thawing is not recommended.
Reconstitution : Centrifuge the vial prior to opening and reconstitute in water to a concentration of 50ng/ul. The initial reconstitution is a crucial step as it assures full solubility of the IL-7. When reconstituting the product, gently pipet and wash down the slides of the vial to ensure full recovery of the protein into solution. Optimal concentration should be determined for specific application and cell lines.
Gene Name : IL7 interleukin 7 [ Homo sapiens ]
Official Symbol : IL7
Synonyms : IL7; interleukin 7; interleukin-7; IL 7; IL-7;
Gene ID : 3574
mRNA Refseq : NM_000880
Protein Refseq : NP_000871
MIM : 146660
UniProt ID : P13232
Chromosome Location : 8q12-q13
Pathway : Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Immune System, organism-specific biosystem; Interleukin-7 signaling, organism-specific biosystem;
Function : cytokine activity; cytokine receptor binding; growth factor activity; growth factor activity; interleukin-7 receptor binding; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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What are the application scenarios of IL7? 10/10/2020

IL7 is widely used in the research and development of immunotherapy protocols, can enhance the body's immune function, for the treatment of cancer, infection, autoimmune diseases and other diseases.

What is the mechanism of IL7 in the treatment of bladder cancer? 11/25/2019

IL7 can activate the body's immune system and enhance the immune cells' attack on bladder cancer.

What is the optimal dose of IL7 in the treatment of leukemia? 07/18/2019

The dosage of IL7 in the treatment of leukemia needs to be calculated individually according to the specific situation of the patient.

Does the efficacy of IL7 in the treatment of infectious diseases? 04/10/2019

It can enhance the function of the body's immune system, and has a certain effect on some infectious diseases.

Are there have any efficacy of IL7 in the treatment of specific cancers? 03/31/2019

Recombinant IL7 protein may have some therapeutic effect on specific cancers by activating T cells, but further clinical studies are needed.

How to prepare IL7? 03/27/2019

This is obtained by recombinant DNA technology, inserting foreign genes into the host expression system, and then through purification and other steps.

Customer Reviews (3)

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Reviews
03/27/2022

    Effective in signal transduction pathway.

    04/17/2021

      IL7 has good absorbability and high bioavailability.

      11/27/2020

        Good stability under different environmental conditions

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