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Recombinant Human POLK, MYC/DDK-tagged

Cat.No.: POLK-837H
Product Overview: Recombinant Human POLK, fused with C-terminal MYC/DDK, was expressed in HEK293 Cells.
Description: External and internal DNA-damaging agents continually threaten the integrity of genetic material in cells. Although a variety of repair mechanisms exist to remove the resulting lesions, some lesions escape repair and block the replication machinery. Members of the Y family of DNA polymerases, such as POLK, permit the continuity of the replication fork by allowing replication through such DNA lesions. Each Y family polymerase has a unique DNA-damage bypass and fidelity profile. POLK is specialized for the extension step of lesion bypass.
Source: HEK293
Species: Human
Tag: MYC/DDK
Molecular Mass: 98.6 kDa
Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration: >50 ug/mL as determined by microplate BCA method
Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name: POLK polymerase (DNA directed) kappa [ Homo sapiens (human) ]
Official Symbol: POLK
Synonyms: POLK; DINP; POLQ; DINB1; polymerase (DNA directed) kappa; DNA polymerase kappa; NP_057302.1; EC 2.7.7.7
Gene ID: 51426
mRNA Refseq: NM_016218
Protein Refseq: NP_057302
MIM: 605650
UniProt ID: Q9UBT6
Chromosome Location: 5q13
Pathway: Fanconi anemia pathway
Function: DNA-directed DNA polymerase activity; damaged DNA binding; metal ion binding

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