Recombinant Human TEK, GST-tagged

• Cat.No.: TEK-3177H
• Product Overview: Recombinant Human TEK protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: C-term-346aa
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: TEK TEK tyrosine kinase, endothelial [ Homo sapiens ]
• Official Symbol: TEK
• Synonyms: TEK; TEK tyrosine kinase, endothelial; venous malformations, multiple cutaneous and mucosal , VMCM; angiopoietin-1 receptor; CD202b; TIE 2; TIE2; VMCM1; hTIE2; p140 TEK; soluble TIE2 variant 1; soluble TIE2 variant 2; endothelial tyrosine kinase; tyrosine-protein kinase receptor TEK; tunica interna endothelial cell kinase; tyrosine-protein kinase receptor TIE-2; tyrosine kinase with Ig and EGF homology domains-2; VMCM; TIE-2; CD202B
• Gene ID: 7010
• mRNA Refseq: NM_000459
• Protein Refseq: NP_000450
• MIM: 600221
• UniProt ID: Q02763
• Chromosome Location: 9p21
• Pathway: Angiogenesis, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Hemostasis, organism-specific biosystem; Rheumatoid arthrit
• Function: ATP binding; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; protein tyrosine kinase activity; receptor activity; transmembrane receptor protein tyrosine kinase activity

Reviews

06/07/2020

Outstanding service! Staff expertise helped us choose the perfect protein.

10/31/2019

Seamless delivery process—ordered, received, and ready for experiments.

03/14/2018

Courteous and efficient customer service made our purchase hassle-free.

Q&As

How does the TEK gene influence vascular development during embryogenesis, and what are the key molecular players involved?

The TEK gene is crucial for vascular development during embryogenesis, coordinating with other genes and signaling pathways to ensure proper formation of the vascular system.

What role does the TEK gene play in pathological angiogenesis, particularly in diseases like cancer?

The TEK gene is implicated in pathological angiogenesis in diseases like cancer, where dysregulation of TIE2 signaling can contribute to aberrant blood vessel formation.

How does the TEK gene contribute to the modulation of vascular permeability?

The TEK gene, through TIE2 signaling, regulates vascular permeability by influencing the integrity of endothelial cell junctions and controlling the passage of molecules across blood vessels.

How does the TEK gene contribute to the maintenance of vascular quiescence, and what molecular processes are involved?

The TEK gene contributes to the maintenance of vascular quiescence by suppressing endothelial cell activation and inflammation, preserving the stability of blood vessels.

How does the TEK gene participate in the regulation of immune responses in the context of vascular inflammation?

The TEK gene, through TIE2 signaling, influences immune responses by modulating interactions between endothelial cells and immune cells during vascular inflammation.