Recombinant Human TPH2, GST-tagged

• Cat.No.: TPH2-3368H
• Product Overview: Recombinant Human TPH2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 1-75aa
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: TPH2 tryptophan hydroxylase 2 [ Homo sapiens ]
• Official Symbol: TPH2
• Synonyms: TPH2; tryptophan hydroxylase 2; tryptophan 5-hydroxylase 2; FLJ37295; NTPH; tryptophan 5-monooxygenase 2; neuronal tryptophan hydroxylase; ADHD7; MGC138871; MGC138872
• Gene ID: 121278
• mRNA Refseq: NM_173353
• Protein Refseq: NP_775489
• MIM: 607478
• UniProt ID: Q8IWU9
• Chromosome Location: 12q15
• Pathway: Amine-derived hormones, organism-specific biosystem; Melatonin biosynthesis, tryptophan =>serotonin => melatonin, organism-specific biosystem; Melatonin biosynthesis, tryptophan => serotonin => melatonin, conserved biosystem
• Function: amino acid binding; iron ion binding; metal ion binding; tryptophan 5-monooxygenase activity

Reviews

01/22/2021

Its consistent and accurate results, combined with its compatibility with various cutting-edge techniques, ensure that data collection and analysis are both reliable and meaningful.

11/10/2018

The TPH2 protein's exceptional performance in ELISA and its successful application in protein electron microscopy structure analysis make it a highly reliable and recommended choice for researchers.

01/24/2018

The manufacturer's commitment to delivering a high-quality product further enhances its reputation and guarantees its suitability for a wide range of research applications.

Q&As

How can TPH2 be targeted for therapeutic interventions?

Targeting TPH2 through pharmacological agents or gene therapies may be explored to modulate serotonin levels and alleviate mood disorders.

What role does TPH2 play in anxiety disorders?

TPH2 dysregulation may lead to imbalances in serotonin, contributing to the pathogenesis of anxiety disorders.

How does TPH2 relate to neurodegenerative disorders?

TPH2 has been studied in the context of neurodegenerative disorders due to its influence on serotonin, which has neuroprotective properties.

Can TPH2 be a target for drug development in psychiatry?

Yes, drugs targeting TPH2 or the serotonin pathway are being investigated for their potential in developing novel psychiatric medications.

Are there genetic factors influencing TPH2 expression?

Yes, genetic variations can affect TPH2 expression, contributing to individual differences in serotonin levels and susceptibility to mood disorders.