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Recombinant Human WNT5A, StrepII-tagged

Cat.No. : WNT5A-206H
Product Overview : Purified, full-length human recombinant WNT5A protein (amino acids 36-380, 345 a.a.) with StrepII tag, produced in human cells. Predicted molecular weight: 38.8 kDa. (Accession NP_003353.2; UniProt P41221)
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Description : The WNT family consists of structurally related signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This protein is a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. It is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis.
Source : Human Cells
Species : Human
Tag : StrepII
Form : Lyophilized from sterile 0.2μm filtered solution in 0.3X PBS with 10% Trehalose (carrier-free).
Protein length : 36-380, 345 a.a.
AA Sequence : FAQVVIEANSWWSLGMNNPVQMSEV YIIGAQPLCSQLAGLSQGQKKLCHL YQDHMQYIGEGAKTGIKECQYQFRH RRWNCSTVDNTSVFGRVMQIGSRET AFTYAVSAAGVVNAMSRACREGELS TCGCSRAARPKDLPRDWLWGGCGDN IDYGYRFAKEFVDARERERIHAKGS YESARILMNLHNNEAGRRTVYNLAD VACKCHGVSGSCSLKTCWLQLADFR KVGDALKEKYDSAAAMRLNSRGKLV QVNSRFNSPTTQDLVYIDPSPDYCV RNESTGSLGTQGRLCNKTSEGMDGE LMCCGRGYDQFKTVQTERCHCKFHW CCYVKCKKCTEIVDQFVCK
Endotoxin : <0.1 eu per ug protein by lal
Purity : >95% pure by SDS-PAGE
Storage : 12 months at -20°C as supplied; 1 month at 4°C after reconstitution. Avoid freeze/thaw cycles.
Reconstitution : Centrifuge the vial prior to opening. Reconstitute in PBS to a concentration of 0.1 mg/ml.
Gene Name : WNT5A wingless-type MMTV integration site family, member 5A [ Homo sapiens ]
Official Symbol : WNT5A
Synonyms : WNT5A; wingless-type MMTV integration site family, member 5A; protein Wnt-5a; hWNT5A; WNT 5A protein; WNT-5A protein;
Gene ID : 7474
mRNA Refseq : NM_001256105
Protein Refseq : NP_001243034
MIM : 164975
UniProt ID : P41221
Chromosome Location : 3p21-p14
Pathway : Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Class B/2 (Secretin family receptors), organism-specific biosystem; DNA damage response (only ATM dependent), organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem;
Function : cytokine activity; frizzled binding; frizzled-2 binding; protein domain specific binding; receptor agonist activity; receptor binding; receptor tyrosine kinase-like orphan receptor binding; sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does WNT5A play in cancer biology? 09/05/2022

Its role in cancer is complex, acting as a tumor suppressor or promoter depending on context.

How does WNT5A interact with its receptors to initiate signal transduction? 04/24/2022

It binds to Frizzled receptors and co-receptors, activating non-canonical Wnt signaling pathways.

In which developmental processes is WNT5A critically involved? 03/14/2022

WNT5A is involved in embryonic development, particularly in limb formation and organogenesis.

How is WNT5A implicated in immune system regulation? 01/03/2022

WNT5A modulates various immune responses, influencing inflammation and cell migration.

What is the primary role of WNT5A in cellular processes? 10/29/2020

WNT5A is crucial in regulating cell proliferation, migration, and differentiation.

What therapeutic strategies are being explored involving WNT5A modulation? 11/14/2019

Strategies include developing WNT5A modulators for potential use in cancer therapy and regenerative medicine.

Are there known genetic mutations in WNT5A associated with specific diseases? 02/27/2019

Genetic mutations and altered expression of WNT5A are linked to developmental disorders and cancer.

Customer Reviews (3)

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Reviews
11/14/2019

    Satisfied with performance, quality.

    08/27/2019

      Great product, satisfied customer.

      02/27/2019

        High purity, works well.

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