Recombinant Human MTOR, MYC/DDK-tagged
Cat.No. : | MTOR-156H |
Product Overview : | Recombinant Human MTOR, fused with C-terminal MYC/DDK, was expressed in HEK293. |
- Specification
- Gene Information
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Description : | The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. |
Source : | HEK293 |
Species : | Human |
Tag : | MYC/DDK |
Molecular Mass : | 288.7 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | MTOR mechanistic target of rapamycin (serine/threonine kinase) [ Homo sapiens (human) ] |
Official Symbol : | MTOR |
Synonyms : | MTOR; FRAP; FRAP1; FRAP2; RAFT1; RAPT1; mechanistic target of rapamycin (serine/threonine kinase); serine/threonine-protein kinase mTOR; rapamycin target protein 1; mammalian target of rapamycin; rapamycin and FKBP12 target 1; FKBP-rapamycin associated protein; rapamycin associated protein FRAP2; FKBP12-rapamycin complex-associated protein 1; FK506 binding protein 12-rapamycin associated protein 2; FK506-binding protein 12-rapamycin complex-associated protein 1; NP_004949.1; EC 2.7.1.1; EC 2.7.11.1 |
Gene ID : | 2475 |
mRNA Refseq : | NM_004958 |
Protein Refseq : | NP_004949 |
MIM : | 601231 |
UniProt ID : | P42345 |
Chromosome Location : | 1p36.2 |
Pathway : | Acute myeloid leukemia; Alpha6-Beta4 Integrin Signaling Pathway; Class I PI3K signaling events mediated by Akt |
Function : | ATP binding; RNA polymerase III type 1 promoter DNA binding; TFIIIC-class transcription factor binding |
Products Types
◆ Recombinant Protein | ||
MTOR-22H | Recombinant Human MTOR Protein, GST tagged | +Inquiry |
MTOR-3539H | Recombinant Human MTOR Protein, His (Fc)-Avi-tagged | +Inquiry |
Mtor-4222M | Recombinant Mouse Mtor Protein, Myc/DDK-tagged | +Inquiry |
MTOR-5792M | Recombinant Mouse MTOR Protein, His (Fc)-Avi-tagged | +Inquiry |
MTOR-3474R | Recombinant Rat MTOR Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
MTOR-4068HCL | Recombinant Human MTOR 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionDysregulation of the MTOR pathway has been linked to various diseases, including cancer, metabolic disorders, and neurological conditions.
Activation of the MTOR pathway can impair the response to immunotherapy by promoting immunosuppressive mechanisms within the tumor microenvironment.
The enhancement of drug efflux pumps, increased repair of DNA damage, and the promotion of cancer stem cell survival are some of the mechanisms by which the MTOR pathway contributes to drug resistance.
Understanding the molecular mechanisms of the MTOR pathway can aid in the development of targeted therapies that specifically inhibit its activity, thereby improving cancer treatment outcomes.
Dysregulation of the MTOR pathway has been linked to metabolic disorders such as obesity, diabetes, and insulin resistance, highlighting its role in metabolic homeostasis.
Customer Reviews (3)
Write a reviewWith its reliable performance and consistent results, the MTOR protein provides researchers with the confidence and accuracy required for successful experimentation.
The MTOR protein stands out as a protein of exceptional quality, perfectly suited to meet the experimental needs of researchers.
One remarkable aspect of working with the MTOR protein is the excellent technical support provided by its manufacturer.
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