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Recombinant Human MTOR, MYC/DDK-tagged

Cat.No. : MTOR-156H
Product Overview : Recombinant Human MTOR, fused with C-terminal MYC/DDK, was expressed in HEK293.
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  • Gene Information
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Description : The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.
Source : HEK293
Species : Human
Tag : MYC/DDK
Molecular Mass : 288.7 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : MTOR mechanistic target of rapamycin (serine/threonine kinase) [ Homo sapiens (human) ]
Official Symbol : MTOR
Synonyms : MTOR; FRAP; FRAP1; FRAP2; RAFT1; RAPT1; mechanistic target of rapamycin (serine/threonine kinase); serine/threonine-protein kinase mTOR; rapamycin target protein 1; mammalian target of rapamycin; rapamycin and FKBP12 target 1; FKBP-rapamycin associated protein; rapamycin associated protein FRAP2; FKBP12-rapamycin complex-associated protein 1; FK506 binding protein 12-rapamycin associated protein 2; FK506-binding protein 12-rapamycin complex-associated protein 1; NP_004949.1; EC 2.7.1.1; EC 2.7.11.1
Gene ID : 2475
mRNA Refseq : NM_004958
Protein Refseq : NP_004949
MIM : 601231
UniProt ID : P42345
Chromosome Location : 1p36.2
Pathway : Acute myeloid leukemia; Alpha6-Beta4 Integrin Signaling Pathway; Class I PI3K signaling events mediated by Akt
Function : ATP binding; RNA polymerase III type 1 promoter DNA binding; TFIIIC-class transcription factor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does dysregulation of the MTOR pathway contribute to the development of certain diseases? 01/01/2022

Dysregulation of the MTOR pathway has been linked to various diseases, including cancer, metabolic disorders, and neurological conditions.

How does the MTOR pathway influence the response to immunotherapy in cancer treatment? 04/19/2021

Activation of the MTOR pathway can impair the response to immunotherapy by promoting immunosuppressive mechanisms within the tumor microenvironment.

What are the mechanisms through which the MTOR pathway contributes to drug resistance in cancer? 01/24/2020

The enhancement of drug efflux pumps, increased repair of DNA damage, and the promotion of cancer stem cell survival are some of the mechanisms by which the MTOR pathway contributes to drug resistance.

How can the knowledge of the MTOR pathway be leveraged to develop novel cancer therapies? 02/28/2019

Understanding the molecular mechanisms of the MTOR pathway can aid in the development of targeted therapies that specifically inhibit its activity, thereby improving cancer treatment outcomes.

What are the implications of MTOR pathway dysregulation in metabolic disorders? 08/28/2018

Dysregulation of the MTOR pathway has been linked to metabolic disorders such as obesity, diabetes, and insulin resistance, highlighting its role in metabolic homeostasis.

Customer Reviews (3)

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Reviews
12/27/2020

    With its reliable performance and consistent results, the MTOR protein provides researchers with the confidence and accuracy required for successful experimentation.

    02/16/2019

      The MTOR protein stands out as a protein of exceptional quality, perfectly suited to meet the experimental needs of researchers.

      12/01/2016

        One remarkable aspect of working with the MTOR protein is the excellent technical support provided by its manufacturer.

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